I have had RA for at least 35 years - mainly prednisone only worked (other meds not so much) Orencia IV once a month, methotrexate for about a year but now effecting Liver enzymes as did 35 yrs ago. At 78 my ligaments, tendons and muscles are tearing and atrophying - due to RA and meds. Always very active - now can hardly walk. Anyone else having this happen?