What is minimum period of Alendronate to minimise Prolia rebound?

I am fairly new here and I am at the same exact spot where you were when you asked this question. I am curious as to what your decision was and where you are at in this stage. I am in good physical shape and exercise daily for 1 hour or more. I would like to stop as well . I would like to know how you are doing.

Also in the same boat, so please let us know your experience and hope.

what ended up happening ? Did you stay on Fosamax and did it prevent rebound fractures?

I stayed on Fosamax post-Prolia and am still on it but only half a dose. Expect to stop entirely this May after 2 years, when I will get a Dexa scan also after 2 years of flying almost blind. I have had no fractures. My blood turnover markers are OK....not as great as I might like but OK.

My situation is considerably different from what I understand about yours. I took only 2 Prolia injections before my bone density improved significantly and stopped Prolia. If I had been on Prolia for 5 years, like you, and based on what I have learned the past few years, I would question whether Fosamax is powerful enough to counter rebound. If I had fractured like you, I would look at taking a bone builder.

The very best Connect thread discussing getting off Prolia is called 'Support for those quitting Prolia.' It contains extensive, well-reasoned discussions with supporting info/studies.

And the very best deep-dive info about OP is a book entitled 'Great Bones' by Keith McCormick.

Finally, I hope you will educate yourself about the use of blood tests (blood turnover markers) that might be helpful with trying to figure out your continued risk of rebound fracture and whether the path you choose is actually working.

Best of luck to you and I hope you can prevent any further fractures.

I have a similar situation. I started Prolia (2 injections ) on the 2nd shot I developed a rash & infection. I was out in Alendronate ( now on my 8 th week.). I do t like some of the side effects & want to stop as well. Other than osteoporosis , I am healthy and I exercise and walk every day. I see my dr (ra) in 4 more weeks. I know he’s going to tell me to stay on something but I’m stressed out also.

I have been on alendronate and have not mad any gains in 3 years. I’m beyond disappointed. Don’t like taking it. Looking and waiting to get into a new dr who deals with this to learn and try other treatments. However they all freak me out

I can't believe the cost you paid for one injection. It is quite disgusting that the pharmaceutical industry makes billion dollars of profits when we need these medications. A fair price we could cope with. You had better look at Dr Aseem Malhotra movie 'First Do No Pharm' that shows the true picture of the Pharmaceutical companies. Dr Aseem may soon be working in America with Kennedy to reduce Obesity. I think Kennedy will need our Dr Aseem. Good luck to all of us who have been affected by these giant money making Pharmaceutical companies.

Did you have a Rebound effect, fractures etc as l am stopping Prolia and going on to alendronate but l am not sure it is powerful enough to prevent the rebound effect of fractures

The current administration supports policies which support deregulation and increased corporate profit at the expense of consumer protection.

I have been on Prolia for severe Osteoporosis for 6 years. The side affects over the last 2 have included increased bone and joint pain, abdominal pain, fatigue, muscle spasms and rashes. The last 2 injections, these side affects lasted on and off for 3 months. My endocrinologist never told me I had to be in it for life. When I told him about them in office with tears, his response was not to let the patients in the waiting room see me cry.