I responded very badly to Prednisone when I was getting it to try to reduce the swelling in my spine post-surgery and relieve the pressure on the spinal cord -- I ended up with steroid-induced diabetes, and the hospital nurses had to give me regular insulin injections (the diabetes cleared up almost immediately after I stopped).

Most people here seem to tolerate steroids fine — I guess I'm an exception — but I still suggest that you talk to your medical team about the Prednisone as well as the ADT as a possible source of any side-effects you're experiencing. I don't know if that's why my oncologists recommended Apalutamide instead of Zytiga for me in 2021 (the -lutamides doen't require a steroid); the TITAN study was also just out, showing a huge improvement in delaying progression and overall survival in patients with mCSPC taking ADT+Apalutamide.

I know a few people that are doing this and it works just great. Many doctors aren’t offering this option, usually, the people I know I’ve had to ask for it. Sounds like you have an enlightened doctor.