I recently switched to Orgovyx after being on Lupron for 7 months. I experienced all the side effects on Lupron almost immediately: (loss of libido, ED, muscle loss, fatigue, hot flashes, 50% genital shrinkage since start of treatment, loss of body hair, skin irritations, bone loss, and higher emotional sensitivity). I'm in my second month of Orgovyx and do not see any real change in side effects. I agree we are all different in our fricken PCa and react differently. I switched to Orgovyx as it is to have a quicker T recovery period once Tx ends and lower CV events.
Everyone should get baseline measures at least for PSA, T, and bone density. I didn't get them until I advocated for them. PSA was 9.52 (3 months prior to Tx) and was reduced to 0.09 after 4 months on Lupron (pretty good). No baseline T or DXA taken. Finally got a T level 5 months later and it was 16 NS/dl - had no baseline T prior other than 10 years ago when my T was close to 1,000. Had a DXA scan a couple of months ago and significant deterioration detected. Will soon start an injection to improve bones. So hopefully with more consistent testing, Orgovyx will do me good.
I have a new oncologist now and he agrees we should be pro-actively monitoring my health.