@notaround Thank you so much for your input. I was on 75 mg of Effexor previously and for some reason I thought it was making me ill. so to avoid withdrawal my doctor put me on 37.5. You know in the past year don't know what works or doesn't work. I keep thinking the medication is making me ill when in fact that is not it. I am looking for relief and can't seem to get it. The CBD oil helps with my back pain, but you may be right tha it does interact. I do have CBD oil w/o THC, but I am going to look further into what you are telling me. I thank you so much. Sometimes I don't know where the grief is where the depression is and then all the body pain. My late husband would want me to continue and to enjoy life and that is one of the reasons I am seeking answers. I do know that I have read so many negative's on here about Effexor and at this point wonder if I tried getting off it because of that I just don't know. It seems so much of a blur right now.