If I remember correctly, it's 3 months on the Tymlos and then after 1 year. I had the Reclast 9 months before that. Don't expect much at 2 months or even 6 months if it's your bones you are doing it for @kper. You need a baseline, which should be done before starting. Or if not soon, asap after starting both. In which case, you might not see any change in the HRT. Wait until your 1-year DEXA TBS test. That will be a good thing to see. Things that come out of one's bloodstream can not be true markers, as what is in the bloodstream is inconsistent at any test. DEXA scans should have the TBS score included so find a source to do that. The bone changes if you are on the TYMLOS will have positive changes 2-3 years AFTER you have stopped the infusion. https://www.medicalnewstoday.com/articles/reclast-infusion-for-osteoporosis#duration