While Prednisone is known for its dramatic results, I have to say that it's Kevzara that has given me my life back. I had the usual dramatic response to Prednisone then couldn't reduce further. Unlike most folks, my response to Kevzara was immediate and dramatic. Within days, I had less pain and greater mobility. Kevzara targets different receptors than Prednisone, and I believe my PMR is more affected by that pathway. If I'm late with a Kevzara dose, my body reminds me. Meanwhile, I'm dropping to 3 mg of Prednisone this week and expect to be down to 1 and off by summertime. My exercise tolerance is (slowly) increasing, sleep is improved, brain fog from pain is almost gone. I'm much better off by every measure to be on only Kevzara than Kevazara+Prednsone. Can't wait to lose this moonface & weight gain and get back to walking and hiking 3 to 5 miles daily.