Anastrozole...has anyone had an increase in glucose or cholesterol

Posted by sandyjr @sandyjr, Jul 22, 2019

Since I started taking anastrozole....June 2018....my glucose and cholesterol readings seem to be increasing...enough for me to be concerned as I do not want to be put on any more medicine...especially for these issues. Has anyone had this problem? I always get copies of my test reports so that I will know what is happening and so that I will not be blindsided at a Dr appointment. Most of the complaints about anastrozole have been about physical discomfort...what about changes in blood tests?

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My cholesterol went up and stayed up, statins and dietary changes had little to effect on this. I still take a maximum statin and eat the best that I can. I am pretty active (sometimes even more than I want). I have been off the anastrazole for a few years but the menopausal symptoms are all still there.
Like @mdr3 said, I became an old lady overnight and seem to continue aging an accelerated rate. I do not worry overmuch about it, as I am happy to still be here. I am not claiming it is always easy, it is not. I am just saying that I choose to be grateful for my life.
Has the statin helped to lower the cholesterol for any of you?

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@auntieoakley

My cholesterol went up and stayed up, statins and dietary changes had little to effect on this. I still take a maximum statin and eat the best that I can. I am pretty active (sometimes even more than I want). I have been off the anastrazole for a few years but the menopausal symptoms are all still there.
Like @mdr3 said, I became an old lady overnight and seem to continue aging an accelerated rate. I do not worry overmuch about it, as I am happy to still be here. I am not claiming it is always easy, it is not. I am just saying that I choose to be grateful for my life.
Has the statin helped to lower the cholesterol for any of you?

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Hard to tell, as I was on a statin before this (5 mg Crestor daily). I was taking it every other day before that. Once I finished chemo and radiation, I felt well enough to use it every day. I looked ten times better during those treatment days than I do now. Afraid to take any supplements other than Vit. D

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@mdr3

Hard to tell, as I was on a statin before this (5 mg Crestor daily). I was taking it every other day before that. Once I finished chemo and radiation, I felt well enough to use it every day. I looked ten times better during those treatment days than I do now. Afraid to take any supplements other than Vit. D

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Ah geez. This is all so hard sometimes. May I ask why you are afraid of supplements. My doctor has me on several.

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@auntieoakley

My cholesterol went up and stayed up, statins and dietary changes had little to effect on this. I still take a maximum statin and eat the best that I can. I am pretty active (sometimes even more than I want). I have been off the anastrazole for a few years but the menopausal symptoms are all still there.
Like @mdr3 said, I became an old lady overnight and seem to continue aging an accelerated rate. I do not worry overmuch about it, as I am happy to still be here. I am not claiming it is always easy, it is not. I am just saying that I choose to be grateful for my life.
Has the statin helped to lower the cholesterol for any of you?

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My A1c has increased after being on Letrozole for 2 yrs. My cholesterol has stayed in a good range with a statin that I have taken even prior to my lumpectomy.

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I had a lumpectomy 5/24, radiation therapy for 1 week, and I am now on anastrozole for the past seven months. My glucose numbers are steadily increasing...cholesterol as well. I am 82 yrs. old and weigh 130 lbs. I teach fitness classes 8 hours weekly. So I get regular cardio and mind/body exercise on a daily basis. I was already on b/p meds, and statins. Increasing those have only led to light-headedness, with no decrease in b/p or cholesterol. Diet changes have only reduced my sodium levels, but have had no effect on the glucose/cholesterol measurements. It's very frustrating to know I am eating reasonably healthy, taking the proper meds, and still not reducing those critical measurements. Any suggestions?

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@janey42

I had a lumpectomy 5/24, radiation therapy for 1 week, and I am now on anastrozole for the past seven months. My glucose numbers are steadily increasing...cholesterol as well. I am 82 yrs. old and weigh 130 lbs. I teach fitness classes 8 hours weekly. So I get regular cardio and mind/body exercise on a daily basis. I was already on b/p meds, and statins. Increasing those have only led to light-headedness, with no decrease in b/p or cholesterol. Diet changes have only reduced my sodium levels, but have had no effect on the glucose/cholesterol measurements. It's very frustrating to know I am eating reasonably healthy, taking the proper meds, and still not reducing those critical measurements. Any suggestions?

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Since I was much younger than you upon diagnosis, I am not sure the medication actions were the same but I did find this to be true while on anastrazole for 10 years and even after stopping it.
I have to watch my sugar intake carefully or my glucose test will come back high.
I also started having cholesterol issues, this has continued, with a maximized statin this stays under control but I hate the side effects of that too. Haha
I had a cardiac calcium CT to make sure that I wasn’t getting blocked arteries and it came back clear.
I had to pay cash for this test but it was worth the peace of mind for $180.
I can’t say for sure this is all from anastrazole but I was in my early 40’s and very, very thin and active at the time.
Have you talked to your doctor at all about this? Did you have high glucose or cholesterol prior to beginning therapy?

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@auntieoakley

Since I was much younger than you upon diagnosis, I am not sure the medication actions were the same but I did find this to be true while on anastrazole for 10 years and even after stopping it.
I have to watch my sugar intake carefully or my glucose test will come back high.
I also started having cholesterol issues, this has continued, with a maximized statin this stays under control but I hate the side effects of that too. Haha
I had a cardiac calcium CT to make sure that I wasn’t getting blocked arteries and it came back clear.
I had to pay cash for this test but it was worth the peace of mind for $180.
I can’t say for sure this is all from anastrazole but I was in my early 40’s and very, very thin and active at the time.
Have you talked to your doctor at all about this? Did you have high glucose or cholesterol prior to beginning therapy?

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I did have high cholesterol and elevated b/p prior to anastrozole therapy. But, both were well-controlled with statins and hydrochlorothiazide. Since having to give up HRT due to BC, all these meds have been replaced, increased and adjusted, but it doesn't seem to help. And the addition of anastrozole seems to have made them useless. Maximizing the dosages causes dizziness for me, and I become concerned about driving. I was wondering if there was another anti-cancer drug that doesn't exacerbate these conditions as much. I do discuss it all with my MDs, but they don't really veer from what's prescribed for these conditions, toxic as they are. BTW, my diet, though not vegan by any means, is reasonably healthy. Small portions, two good meals daily. Light snacks...mostly fruit, very little red meat monthly, etc. It's very frustrating.

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Before starting Anastrozole, 3 years ago, at age 62 I had no issues with high cholesterol, glucose or high BP. Within a year my bad cholesterol shot up and my primary wanted to put me on a statin, which I refused. I started taking ezetimibe which is supposed to block the absorption of cholesterol and that appears to be working. My heart work up last year came back clear so I’m pretty happy that I didn’t go down the statin path.

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@gldilli

Before starting Anastrozole, 3 years ago, at age 62 I had no issues with high cholesterol, glucose or high BP. Within a year my bad cholesterol shot up and my primary wanted to put me on a statin, which I refused. I started taking ezetimibe which is supposed to block the absorption of cholesterol and that appears to be working. My heart work up last year came back clear so I’m pretty happy that I didn’t go down the statin path.

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That's very interesting. Do you suffer any side-effects from this medication?

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@janey42

I had a lumpectomy 5/24, radiation therapy for 1 week, and I am now on anastrozole for the past seven months. My glucose numbers are steadily increasing...cholesterol as well. I am 82 yrs. old and weigh 130 lbs. I teach fitness classes 8 hours weekly. So I get regular cardio and mind/body exercise on a daily basis. I was already on b/p meds, and statins. Increasing those have only led to light-headedness, with no decrease in b/p or cholesterol. Diet changes have only reduced my sodium levels, but have had no effect on the glucose/cholesterol measurements. It's very frustrating to know I am eating reasonably healthy, taking the proper meds, and still not reducing those critical measurements. Any suggestions?

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Yes mine up too

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