@joyh
Been on Entresto for about 10 years since it came out. Funny insurance would not cover it saying other blood pressure medicine available. My Heart Failure doctor at Mayo Jacksonville appealed it saying it was not a blood pressure medicine but a medicine to treat heart failure.

BCBS Federal agreed with my HF doctor and covered Entresto. So, I went from paying nothing for it (Entresto covered it since insurance denied) to paying $125.00 every 3 months.

It did not improve my EF but kept it from getting any worse. My EF was going down and down and the Entresto (I think) stopped the decrease and have had the same EF for 10 years.

I did have some side effects (I was also put on carvedilol) and my heart rate went down into 30's. I have a ICD/Pacemaker so Pace Clinic up my pacing to 70 to offset this. The first couple of weeks I had a lot of fatigue and was told this would pass as the body compensates for the medication. And that was correct it went away.

So, for me Entresto worked, and I exercise every day for 1-2 hours.