Any transplant recipients get chemo for bladder cancer?

Thanks. Very helpful information.

My husband is 2 years post diagnosis for high grade muscle invasive urothelial cell carcinoma. Located in a pouch off the bladder, he had a partial bladder removal, just the pouch, Chemo for months after, then on to BCG in the bladder. He tolerated Cisplatin and Gemcytobine well but the BCG did not control the tumor regrowth in the bladder. He has had 4 TURBT surgeries in the last year and a half and luckily each time the masses had not invaded the muscle of the bladder wall. He spent the last 5 months on Keytruda, but still had a tiny new bladder growth in July. He has decided to have the bladder removed and a neobladder surgery with his surgeon at Mayo, Dr, Karnes. He wants to avoid an ostomy if at all possible, and building a new bladder out of small intestine is an option. I would love to hear from anyone who knows someone who has had this surgery.

Sue, you may be interested in this discussion:
- Neobladder Replacement vs. Stoma https://connect.mayoclinic.org/discussion/neo-bladder-replacement/

I think @pameladstone @kwagner @madebacco may have experiences with a neobladder to share with you.

Sue, when is surgery scheduled for?

He is scheduled with Dr. Karnes in Rochester Dec. 13. THat link was quite helpful, thank you.

Name: R Mahesh age 67
Hospital : Fortis , in Mumbai , India

Right Urethral carcinoma -

Present state: no problem, urine is clear. Not much effect post chemo for lymph nodes.

Need views.

Right Ureter carcinoma was detected in March 2020. Subsequently in April itself surgery of tumor was done. Biopsy revealed high grade carcinoma. Option of cystoscopy. So This was followed by 3 Checkscopy were done in a gap of every 3 months. In December 2020 pet scan revealed metastasis in para aortic lymph nodes. ButNo cancer in original site. At this point chemo treatment started and took 5 cycles of chemo. Subsequently in April 2021 again pet scan was done. And it was all clear both original ureter and lymph nodes. In August 2021 sonography of KUB was done and that was also clear. Our Oncologist was satisfied with report and asked us to come only in January 2022. However we happened to meet the urologist who did the original surgery and he insisted that pet does not show inside of bladder and the case being of high grade cancer we should do checkscopy. We did the Checkscopy the report of which has also been sent you subsequently . In his report he has now suggested removal of kidney ureter and part of bladder. So our query is when there is no cancer in the body should go for removal of the organs now. What would be your suggestions for future treatment..

Hi Mahesh, you ask questions that only medical professionals who can review the medical records could answer. If you would like to seek the opinion of Mayo Clinic experts, please see the contact information for international patients here: http://mayocl.in/1mtmR63

HI, Had kidney transplant in 1992, still going strong. Diagnosed with squamous cell muscle-invasive cancer of bladder in July 2022. Had radical cystectomy, hysterectomy and ileal conduit. Diagnosed in September 2023 with regional reu=current cancer, two tumours. Require chemo now, but they have chosen Carboplatin and Gemcitabine and not Cisplatin.Anyone been through this and anyone changed chemo if this did not respond adequately? How is your transplant? Did cancer respond to this treatment?I am female, 54 yrs of age.

Hi… I am 14 years out from a double Lung Transplant. My high-grade bladder cancer non-muscle invasive was non-responsive to BCG. My current physician was recommending a study with Oncofid…. A chemo treatment essentially. However, at some point I’m gonna need another Lung Transplant most then is required to be two years past cancer, which is my dilemma. I am considering bladder removal at Mayo in Jacksonville. Most of the first second and third opinions have said that most of the treatment options are like kicking the can down the street… And the cancer is likely to come back for immune compromised. Anybody’s thoughts are welcomed and I will keep you posted.

Hi....I met with my transplant team at MUSC South Carolina...they supported cystectomy over chemotreatment due to reported outcomes. I am waiting for Mayo Jacksonville to schedule my surgery ( ileal conduit). I am sorry to hear your cancer has appeared again. May I ask where? Is your chemo to the body?
I am an almost 62-year-old male. I have good fitness/lifestyle despite 40% lung function.

@lorcansc, how are you doing? Did you get a date for the cystectomy?