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@smurf

While tapering down on Effexor, I had just cut my dose in 1/2, so I was at 125 mg. I could not function at all. I just sat at my computer in a fog, crying. My cognitive ability was decreased. I called my doctor and she said to start the Prozac immediately instead of waiting until I was completely off. Well Prozac did nothing for me at that point. I had to go back to 225 mg. I have been Effexor XR since 1998 or 1999. This medication is the only one that works for me. When I was a teenager, Prozac worked but not now.

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PS I don’t know if I’ll ever get off this med

@smurf
Saw this formula on https://www.depressionforums.org/forums/topic/107532-coming-off-of-effexor-with-prozac-bridge/--
When you cross-titrate between two antidepressants, as you go down on the antidepressant you want to quit, you go up on the antidepressant you are titrating to--so as you go down on Effexor, you go up on Prozac. Then if you want to quit Prozac, it should be easier than quitting Effexor because Prozac has such a long half-life it creates its own tapering effect.

So if you started on 300 mg Effexor + 20 mg Prozac, your titration would look like the following:
300 mg Effexor + 20 mg Prozac
225 mg Effexor + 40 mg Prozac
150 mg Effexor + 60 mg Prozac
75 mg Effexor + 80 mg Prozac
Discontinue Effexor + 80 mg Prozac (or 100 mg Prozac if your pdoc is willing to go above the max dose, which is common to do)

Or if you down-titrate by 37.5 mg:
300 mg Effexor + 20 mg Prozac
262.5 mg Effexor + 30 mg Prozac
225 mg Effexor + 40 mg Prozac
187.5 mg Effexor + 50 mg Prozac
150 mg Effexor + 60 mg Prozac
112.5 mg Effexor + 70 mg Prozac
75 mg Effexor + 80 mg Prozac
37.5 mg Effexor + 80 mg Prozac (90 mg)
Discontinue Effexor + 80 mg Prozac (100 mg)

If you have issues with anxiety/irritability/etc., then you can take a benzo temporarily, like Xanax, Ativan (short-acting), Klonopin, or Valium (long-acting), etc.

Or alternatively--
You could try a much slower taper off Effexor and when you get to the lowest dosage possible on Effexor, replace, or “bridge” it with Prozac. Surviving Antidepressants recommends tapering by 10% of your current dose with at a hold of at least four weeks before your next decrease. Some people may have to taper at an even more conservative rate as they are very sensitive to even the smallest drops.
Then, you taper off Prozac; withdrawal symptoms are consider unusual when discontinuing Prozac.