When I went to see my endocrinologist about TRT (at the request of my MO since my T had not recovered 18 months post ADT/Lupron)he ordered initial labs including LH, FSH, T, PSA and CBC. He suggested trying Clomid only if the LH/FSH was low, indicating the hypothalamic/pituitary axis had not gotten the message that the T was low and needed LH to stimulate the testicles to produce T. My LH and FSH were much higher than normal, indicating that the testicles were "dead" and couldn't produce T anymore, so called primary hypogonadism. In that case, Clomid wouldn't help because LH was already high. So, straight to TRT and I fell great and PSA remains undetectable.