Finally after mammogram and blood work nurse practitioner perscribed .025 estradiol patch and progesterin at night as well as estradiol cream. I am 72 and went through the scare years ago and stopped therapy. After a recent bone scan had deveoped pretty high scores for osteo and same nurse said possibly prolia injections might work and referred me to a rheumatologist. More blood work to see if i would "qualify" for Prolia ensued. After researching those side effects went in total bone strenthening mode of resistance training thinking the side effects for some have been scary. So now am hoping that estrogen therapy and resistant training might be the best option. Seems calcium levels in blood as well as test for hypopararhyroid are a bit high and that prohibits taking this injection are not a good idea. Keeping calm to keep cortisol at bay may help. Prayers too...for all of us 10+ years left behind. Incidentally, the nurse who was around 62 was on HRT and seemed to gloat (smile) when telling me it was too late for me. I am not giving up though. If anyone who might be a few years older and took HRT after 10 years of menapause with promising results would so love to hear of your journey!