Hello, the Amitriptyline helped the first day I started taking it. I take 30mg along with the Lorazepam. I take the Amitriptyline about 2 hours before bedtime. It helps my anxiety, sleep and mild depression. I had hip replacement surgery in October, and before the surgery I had alot of pain and was also taking 3900mg of Arthritis strength Tylenol and 1800mg Ibuprofen daily for about 6 months. But after I had my hip replacement surgery, I didn't need the Ibuprofen and Tylenol anymore. Of course took a pain med right after surgery.....but the surgery was a complete success and recovery was short and easy! I couldn't be happier now! I am in absolutely no pain now. The hip was my only pain issue. I'm an active 64 year old and got back to doing the things I love. Long walks, hiking in the woods, bike riding... .I feel the Amitriptyline along with the Lorazepam help me greatly in stressful situations. Before I would get stressed out in a particular situation and now I don't. It's made me a calmer, anxiety free person. I'm very happy.