My Autoimmune Journey: From 1:5120 to 1:320 ANA

Posted by hamzaw @hamzaw, Jan 20 6:07am

Hey everyone,

I wanted to share my autoimmune journey and the steps I’ve taken to improve my ANA levels over the past year. For those who don’t know, a positive ANA result indicates an autoimmune condition, but it doesn’t always point to a specific disease. My journey has been full of trial and error, but I’ve managed to bring my ANA titer down from 1:5120 to 1:320, and I’m determined to lower it even further to under 1:80.

What I Did to Improve

Dietary Changes:

The best results came when I completely cut out gluten, dairy, and sugar from my diet. This step alone had the most significant impact on my inflammation and symptoms.

I focused on phytonutrient-rich foods like salads, green veggies, berries, and pasteurized sugar-free juices, especially berry juices. These foods became staples in my routine.

I incorporated 3-4 tablespoons of extra virgin olive oil (EVOO) daily, vegan protein shakes, and clean meals like chicken and rice.

Fiber intake was a priority, but I didn’t always hit my target of 40-50 grams per day. On most days, I managed 10-30 grams, using basil seeds, chia seeds, and psyllium husk to boost my intake.

From time to time, I also added dark chocolate or cacao powder to my shakes for its antioxidant benefits.

Additionally, I included collagen in my diet occasionally, either through bone broth or collagen supplements, which helped support my gut health and overall recovery.

Supplement Protocol:

I took a number of supplements, but to keep this section brief, I’ll only be mentioning the most important ones that I think were the most helpful. These included:

Vitamin D3

Omega-3 fish oil

Probiotics

Turmeric (curcumin)

Magnesium

Zinc

Vitamin C

Lifestyle Adjustments:

Sleep: Sleep was a key focus for me, and I took several steps to improve it.

I used melatonin (1mg, 2mg, or 3mg, never exceeding 3mg) to help regulate my sleep.

I tracked my deep sleep and REM sleep using a smartwatch, which gave me insights into my sleep quality.

To further improve my sleep environment, I used an eye cover to block out light.

Exercise: While I didn’t follow a strict five-day plan, I aimed to go to the gym consistently at least three times per week. This helped boost my energy and overall health.

No Medications:

One of the most important things I want to highlight is that I did this completely naturally, without using any steroids or medications. I was off all medications throughout this year, relying entirely on diet, supplements, and lifestyle changes to improve my health.

The Resources That Helped Me

Throughout this journey, I’ve learned so much from amazing experts and books that were incredibly helpful in shaping my protocol. These resources not only informed my approach but also provided hope and actionable steps for healing:

Amy Myers, MD, author of The Autoimmune Solution. Her book is a must-read for anyone dealing with autoimmune conditions and seeking a structured, comprehensive guide to healing.

Mark Hyman, MD, his insights into root cause approaches to health are transformative. He has also appeared on numerous podcasts, which are a great way to learn from his expertise and gain valuable health insights.

Dr. Chanu Dasari, MD, whose expertise in autoimmune healing and dietary strategies, especially through The Phytodiet Primer, has been invaluable.

Books like Beat Autoimmune by Palmer Kippola, The Autoimmune Fix by Tom O’Brien, and The Phytodiet Primer by Chanu Dasari provided practical strategies and tools for managing and reversing autoimmunity. These books are highly recommended for their actionable advice and deep insights into the causes and solutions for autoimmune conditions.

I highly encourage anyone on a similar journey to explore these experts and their work—their knowledge can make a huge difference in your healing process.

The Results So Far

ANA levels: From 1:5120 to 1:320 in one year.

Symptoms: My vasculitis and joint pain are 90% better. Flare-ups are minimal and mostly linked to specific triggers I can now identify.

Energy: I feel much more balanced, although I’m still fine-tuning my routine for optimal recovery.

What I’m Doing Next

Gut Healing:

Gradually reintroducing probiotics with diverse strains using kefir and Greek yogurt.

Rotating supplements and prebiotics to enhance gut flora diversity.

Long-Term Goals:

Lower my ANA to under 1:80 and maintain it through a sustainable lifestyle.

Continue to prioritise sleep, stress reduction, and regular movement.

Why I’m Sharing This

I’m sharing my story in the hope that it might help someone who is on a similar journey, or that someone might share insights to help me improve on something I may have missed.

I’ll also be updating this post as my ANA levels change (and hopefully lower).

If you have any questions about my journey, supplements, or routines, please feel free to ask—I’d love to help in any way I can.

Interested in more discussions like this? Go to the Autoimmune Diseases Support Group.

@windyshores

@hamzaw the ANA with reflex panel may be different from the testing you have had. NOt sure. But after 25 years of the usual testing I recently was discovered to have very high centromere antibodies, and this was the first time I had seen tests for that. From Quest regarding the ANA with reflex panel:

Test Details
Includes
ANA Screen, IFA, with Reflex to Titer and Pattern
DNA (ds) Antibody, Crithidia IFA with Reflex to Titer
Chromatin (Nucleosomal) Antibody
Sm Antibody
Sm/RNP Antibody
RNP Antibody
Sjogren's Antibodies (SS-A, SS-B)
Scleroderma Antibody (Scl-70)
Jo-1 Antibody
Centromere B Antibody
Complement Component C3c and C4c
Cardiolipin Antibodies (IgA, IgG, IgM)
Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM)
Rheumatoid Factor (IgA, IgG, IgM)
Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
Mutated Citrullinated Vimentin (MCV) Antibody
Thyroid Peroxidase Antibodies (TPO)

If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).

If the DNA (ds) Antibody Screen is positive, then DNA (ds) Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

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I wasn’t aware of this—thank you for sharing the information!

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I am starting with a functional medicine practice this month to start this journey myself.

As you well know, it takes years to get an official diagnosis of anything. Even with a high titer ANA. Mine is 1:1280.

I'm struggling with resentment that I have to make all these changes and I have to make them in a budget-friendly way that includes my husband and son. I cannot get either of them to take on the responsibility for feeding themselves, and we can't really afford 2 or 3 separate diets anyway.

I've decided it doesn't matter. I can be mad. I can have hurt feelings. But I have to figure out the changes anyway if I want to live.

Is it fair? No. It's sexist af. But it is what it is.

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@windyshores

After 23 years of symptoms and a 2006 lupus diagnosis, my PCP (not rheumatology!) did an ANA with relfec panel and my anti-centromere antibodies are sky high (limited scleroderma). I am now being followed annually by a rheumatologist who specializes in that, and they did a lot of testing of kidneys, lung and heart to assess my status.

I get systemically ill in the sun. Other than that it is hard to tell which of my pain and neuro issues are due to autoimmunity. I also had a likely paraneoplastic syndrome, an autoimmune reaction to breast cancer. There is "something oging on" but at this point I don't care about labels, since I don't want to take immune suppressants. I did Plaquenil for years but cannot take it anymore (eyes, and also I have a borderline QTc syndrome).

I did an elimination diet in 2006. Eliminated gluten, dairy, salmon, avocado, nuts (both kinds), chocolate, soy, citrus, canola oil. Have gone back on soy in a limited way. I react to pitted fruits in excess. I believe gluten and dairy were contributing to inflammation/paresthesias but some of the other ones were actual allergies.

Tai chi helps me a lot. At the start of class all my neuro sensations are triggered but by the end my body is calmed.

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Hi there..... The words that stood out for me that resonated was Labels. My Doctor said no matter how much money you spend going to specialist they are only going to give you another Title... but what we really need to do is just treat the symptoms. I am HLA-B27 positive which is marker for Lupus Genetic's... my grandma also had this. I have every single sypmtom of Lupus and Fibromyalgia... then add in Neuro Auto Immune after Shingles, now the Heart Specialist says Raynauds probably as well.
Once thing i know is a can't work like i used to when i was younger, which in turn leads to less tiredness and less stress by saying no to people.
Acidic Foods are bad for my joints, and so is Gluten/Wheat and and have been better with my tummy not feeling like i am 10 months pregnant haha
As for light and sound sensitivity and everything else that goes with these autoimmune i think we must manage best we can
I might try Tai Chi thankyou for mentioning that...
Wishing you the most lovely day/week ahead
Take Care from Australia

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Hi there..... The words that stood out for me that resonated was Labels. My Doctor said no matter how much money you spend going to specialist they are only going to give you another Title... but what we really need to do is just treat the symptoms. I am HLA-B27 positive which is marker for Lupus Genetic's... my grandma also had this. I have every single sypmtom of Lupus and Fibromyalgia... then add in Neuro Auto Immune after Shingles, now the Heart Specialist says Raynauds probably as well.
Once thing i know is a can't work like i used to when i was younger, which in turn leads to less tiredness and less stress by saying no to people.
Acidic Foods are bad for my joints, and so is Gluten/Wheat and and have been better with my tummy not feeling like i am 10 months pregnant haha
As for light and sound sensitivity and everything else that goes with these autoimmune i think we must manage best we can

Wishing you the most lovely day/week ahead
Take Care from Australia

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@hamzaw

Yes, I did ENA and anti-dsDNA tests, as suggested by the rheumatologist, but all of them came back negative. So, the only marker I have to focus on is ANA.

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If you do the Quest ANA lab with titer and reflex, you will get ICAP's (International Consensus on ANA Patterns) AC codes. These codes represent general consensus on certain patterns and what they represent. My AC codes indicated systemic sclerosis, primarily. None of the ENA antibodies cover that. I had indications of systemic sclerosis (scleroderma), systemic sclerosis/polymyositis overlap, MCTD, SLE and Sjogren's syndrome. Only the latter two might be covered by ENA.

It is lazy for a rheumatologist not to bother to get those AC codes. They can be very important.

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@larak

If you do the Quest ANA lab with titer and reflex, you will get ICAP's (International Consensus on ANA Patterns) AC codes. These codes represent general consensus on certain patterns and what they represent. My AC codes indicated systemic sclerosis, primarily. None of the ENA antibodies cover that. I had indications of systemic sclerosis (scleroderma), systemic sclerosis/polymyositis overlap, MCTD, SLE and Sjogren's syndrome. Only the latter two might be covered by ENA.

It is lazy for a rheumatologist not to bother to get those AC codes. They can be very important.

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Hi could you give me the AC code on my blood draw? I was diagnosed with MCTD 2 weeks ago. Kind of overwhelming at first for ne

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Congrats to to you!!! How long have you had this disease?

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@sonnyforee10

Hi could you give me the AC code on my blood draw? I was diagnosed with MCTD 2 weeks ago. Kind of overwhelming at first for ne

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I can't really do that. It would need to be included on your ANA lab report. The lab tech would examine your ANA pattern and determine which of the ICAP patterns matched. The AC codes are based on scientific consensus of what the various cellular patterns mean reached by members of ICAP.

But the AC codes are only helpful to narrow down a diagnosis, which it sounds like you already have. 🙂

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@sonnyforee10

Hi could you give me the AC code on my blood draw? I was diagnosed with MCTD 2 weeks ago. Kind of overwhelming at first for ne

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https://www.euroimmun.de/fileadmin/user_upload/News/Professional-articles/HA_1500_L_UK_D.pdf
Not sure if this gives you any of the information you are looking for.

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@larak

I can't really do that. It would need to be included on your ANA lab report. The lab tech would examine your ANA pattern and determine which of the ICAP patterns matched. The AC codes are based on scientific consensus of what the various cellular patterns mean reached by members of ICAP.

But the AC codes are only helpful to narrow down a diagnosis, which it sounds like you already have. 🙂

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Thanks for info I have another blood draw Saturday I’ll be sure to ask person drawing blood and my rheumatologist. Thanks again. How are feeling today? I’m new to this disease still learning about it anything you would like to share to inform of what to expect? Would appreciate any information

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