1. < Prostate Cancer

Lupron: Anyone have muscle weakness and severe leg pain?

Posted by kam23 @kam23, Jul 14, 2023

I have PC and have been on Lupron injections every 3 months for 15 months. I am experiencing severe leg pain in hamstrings and glutes. Has anyone else experienced this or tried monthly shots?

This has been getting worse for the last 3-4 weeks. I’m afraid I’ll be in a wheelchair or have to stop this form of testosterone elimination therapy.

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alrunner | @alrunner | Feb 4 7:57am
In reply to @shimutale "How are your hot flashes like? Mine have been hectic coupled with serious sweating at almost..." + (show)
@shimutale

How are your hot flashes like? Mine have been hectic coupled with serious sweating at almost hourly intervals. I live in Zambia, Southern Africa and Livingstone in particular which is one of the hottest places in the country. I was commenced on Luprodex injection and Bicalutimide 50mg tablets in March 2023 (every 3 months). The 2nd one was in July 2024 and had the last one in October 2024 before under going Prostatectomy on 5th November 2024. Three months down the line, still experiencing serious hot flashes and sweating. Wonder when these side effects will go down

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I am coming up on 7 months since Lupron injection and thankfully my leg pain during runs are just now reducing however I can’t say the same for the hot flashes. It does seem ,similar to yours every hour or so and when they occur I sweat enough for shirt to be wet. My wife believes they are reducing in occurrence but I haven’t noticed. Hopeful if legs are feeling better that soon these hot flashes will be gone. Knowing what ladies go through I really shouldn’t complain as some day mine will be gone. Best of luck, get healthy.

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shepper | @shepper | Feb 4 10:01am

SUMMARY: Gleason 9, Group 5, with local spread as far as we know.

I am currently 54 (I started LUPRON at 52). I have been on Lupron and Abariterone (Zytiga) with prednisone for two years. I will be done in March with the Abariterone, but LUPRON will stay for at least another year or possibly life. This is the plan. I have constant leg pain ranging from 2 to 9, which makes it hard to walk long distances. I also have trouble climbing stairs. Most days, it's somewhere between 2 to 9.

I had an RP, and then six months later, cancer reoccurred, so I went through 35 rounds of radiation and ADT. Along with leg pain/weakness, I have days of extreme fatigue. I also have memory problems that cause me to stop mid-sentence to think of what I need to say next. It can be a challenge. I still walk at least a mile most days and do resistance training about 4 to 5 days a week.

Who knew Testosterone is such a critical chemical?

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johnnyw | @johnnyw | Feb 4 12:28pm
In reply to @jimbo12 "(1) I am an outlier. (2) I was a teenager in the 1950s!!! (3) I took..." + (show)
@jimbo12

(1) I am an outlier. (2) I was a teenager in the 1950s!!! (3) I took ONLY two shots of Lupron and stopped in 2022. (4) I was too stupid to realize that without testosterone, I would lose my muscle mass. The doctor never told me. (5) I used to walk 4 or 5 miles every day to do errands. Walking was my only pleasure. (6) I have NOT done so for TWO years now because of muscle weakness. (7) Because I am so old, I may never regain my pre-Lupron muscle mass before I die. (8) But when I read here about the terrible suffering of so many other men, I am ashamed to wallow in self-pity.

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Hi. I'm 76. I have had significant "muscle wasting", too. This was before any treatments. I've had one Lupron shot and will start abiraterone within a few days when it arrives. Will take prednisone to offset the side effects (the damage ) of the abiraterone. Medical technology seems so primitive! I too was a walker, long distance, then however triggered, aggressive cancer hit, lesions multiplied. I must say, aspirin and celecoxib greatly help. I wish you the best.

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azp52 | @azp52 | Feb 5 9:24am

90 days on Lupron for PC lymph node metastasis. Joint and muscle pain from hips down is unmistakable post injection. I have had CRPS in the right extremity (leg, foot) for 14 years. That pain is what I characterized as extreme. About 4 - 6 weeks into Lupron, the CRPS pain (I didn't think could worsen) became intensified and is now horrific! As I mentioned, the pain in the hips, muscles/joints in both legs is very real and all started after Lupron. Clearly a correlation. Causation, perhaps.

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graybeard46 | @graybeard46 | Feb 5 11:44am
In reply to @alrunner "I was a pretty good marathon with decent speed running 30-40 miles a week. Received a..." + (show)
@alrunner

I was a pretty good marathon with decent speed running 30-40 miles a week. Received a Lupron injection 6 months ago and completed Proton radiation 4 months ago. PSA is was tested 2 days ago and is undetectable. For past 2 months I have been dealing with leg pain during runs staring in mile 2 or so. Legs feel like mile 30 of a marathon with so much discomfort I only managed 4 slow painful miles today. Doctors don’t give me a definitive answer.

I know I am lucky to be out there but can anyone tell me of similar experience and if you ever got past the leg pain. This only happens when I run.

Of course I have other side effects like hot flashes.

Thank you
Al runner

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I have been getting cramps in my thighs almost every day night 🤷‍♂️

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stevieg | @stevieg | Feb 5 4:43pm

I get cramps in my calf’s

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