@bill60 Welcome to Mayo Clinic Connect! Topical treatments can have different effects on us. @davef gave you some great tips!

As fluorouracil starts to work, you might get reaction in an area where you didn't apply it. Not to worry, it just means the medication is tracking down the bad stuff and fighting it. I remember the first time I had that happen to me, rushing back to the dermatologist and their amused response to my concern! Be careful about using any lotions while you do this, as it will negate some of the medication action if you use anything in the same area. After the redness and scabbing starts to go away, it's okay to go back to a light lotion. Stay out of the sun! Cover up! I like to think that when I see the redness appearing, it means things are working and I am taking care of myself. Oftentimes that redness appears on my face, and oh well! just ignore the stares from people.
Ginger