I also took Zometa shots. All I can say is watch your teeth!! The shot didn't bother me, but my teeth are now crooked and the two crowns I have in front now have to be replaced due to the bone shifting in my mouth. I look like Bucky Beaver!! Had I known that Zometa affected the bone in your mouth, I would have refused it. I will also be looking into Invisalign to straighten out my bottom teeth and the molar on top that has moved and now hits my tongue all the time. Makes it very sore and hard to talk at times.