Anyone had Breast Cancer Index test say that 10 years beneficial?

Posted by sirene @sirene, Jan 28 7:04pm

I am almost 2 years on Letrozole and my oncologist did the breast cancer index on me and it came back 5.4 and says that I would benefit from taking it 10 years. Has anyone else received a yes and how are you doing on the extended therapy? Has anyone had a recurrence even though they are on the extended therapy?

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First, I am glad to hear your doctor did this test. Five years ago my doctors had never heard of it. I gather it is now in the NCCN guidelines.

My score was 5.7 but it showed no benefit to extended treatment. I was disappointed. I had planned to do 7 years because at that time it was theorized that 7 was as good as 10, or, at least, almost as good. I haven't kept up on that and don't know if that is still seen as true.

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@windyshores

First, I am glad to hear your doctor did this test. Five years ago my doctors had never heard of it. I gather it is now in the NCCN guidelines.

My score was 5.7 but it showed no benefit to extended treatment. I was disappointed. I had planned to do 7 years because at that time it was theorized that 7 was as good as 10, or, at least, almost as good. I haven't kept up on that and don't know if that is still seen as true.

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Thank you for your response. I will be discussing with my dr soon. Were you hormone positive, her 2-? What stage if you don't mind me asking? I was stage 1A, hormone positive, her 1-. I did not have to have chemo nor radiation but did have to have a 2nd surgery due to unclear margins.

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@sirene

Thank you for your response. I will be discussing with my dr soon. Were you hormone positive, her 2-? What stage if you don't mind me asking? I was stage 1A, hormone positive, her 1-. I did not have to have chemo nor radiation but did have to have a 2nd surgery due to unclear margins.

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@sirene I had a grade 3, stage 1 (1.5cm) tumor that was mixed ductal and lobular. I was first told, after biopsy, that it was HER2+, then after surgery, with 3 opinions, got several equivocals followed by negatives.

I had a low Oncotype score despite the grade 3 and relatively high ki67%. No radiation or chemo, 5 years of letrozole. Double mastectomy.

I also had lymphovascular invasion which is not included in staging or in Oncotye testing but I have read it is equivalent to one positive node.

I am ten years out knock on wood.

Breast Cancer Index folks told me they were changing their classification of risk. At 5.7 % I was "high risk" on the BCI, but this was the same as Oncotype's "low risk" at 6%!

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I had the DCISxion and came back 92 (high). I refused Tamoxifen and other drugs. It made no sense ot me to take a known carcinogenic drug when I just got rid of my cancer cells. Every has their own thoughts. No right or wrong.

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@windyshores

@sirene I had a grade 3, stage 1 (1.5cm) tumor that was mixed ductal and lobular. I was first told, after biopsy, that it was HER2+, then after surgery, with 3 opinions, got several equivocals followed by negatives.

I had a low Oncotype score despite the grade 3 and relatively high ki67%. No radiation or chemo, 5 years of letrozole. Double mastectomy.

I also had lymphovascular invasion which is not included in staging or in Oncotye testing but I have read it is equivalent to one positive node.

I am ten years out knock on wood.

Breast Cancer Index folks told me they were changing their classification of risk. At 5.7 % I was "high risk" on the BCI, but this was the same as Oncotype's "low risk" at 6%!

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Thank you @windyshores. I need to call the Breast Cancer Index people to see what they are saying about mine. My Oncotype score was 21 (I am 66) with 7% chance of recurrence and the BCI is 5.4.
Was your Ki67 the same from the biopsy as it was for the surgical pathology? Mine were different. The biopsy was much higher on mine, 41% as compared to 14.9% on the surgical pathology.

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@meeshodge

I had the DCISxion and came back 92 (high). I refused Tamoxifen and other drugs. It made no sense ot me to take a known carcinogenic drug when I just got rid of my cancer cells. Every has their own thoughts. No right or wrong.

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@meeshodge do you mean that your oncotype was 92? Or your estrogen? Thanks.

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@sirene

@meeshodge do you mean that your oncotype was 92? Or your estrogen? Thanks.

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PreludeDX/DCISionRT was 9.2...not 92....I forgot the decimal
https://preludedx.com/patients/

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@sirene

Thank you @windyshores. I need to call the Breast Cancer Index people to see what they are saying about mine. My Oncotype score was 21 (I am 66) with 7% chance of recurrence and the BCI is 5.4.
Was your Ki67 the same from the biopsy as it was for the surgical pathology? Mine were different. The biopsy was much higher on mine, 41% as compared to 14.9% on the surgical pathology.

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@sirene there was no ki67% from my biopsy. My biopsy was probably primarily ductal and the tumor itself was mixed ductal/lobular. The biopsy was HER2+ and I bought a wig. Thank heavens I went elsewhere. I was later told the biopsy was mainly the ductal part and might have been HER2+ but the tumor as a whole was not. My 4th opinion tested HER2 with 60 cells instead of 20 to reassure me.

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@meeshodge

PreludeDX/DCISionRT was 9.2...not 92....I forgot the decimal
https://preludedx.com/patients/

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Thank you. I have never heard of this test, but I see that it is for DCIS.

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@windyshores

@sirene I had a grade 3, stage 1 (1.5cm) tumor that was mixed ductal and lobular. I was first told, after biopsy, that it was HER2+, then after surgery, with 3 opinions, got several equivocals followed by negatives.

I had a low Oncotype score despite the grade 3 and relatively high ki67%. No radiation or chemo, 5 years of letrozole. Double mastectomy.

I also had lymphovascular invasion which is not included in staging or in Oncotye testing but I have read it is equivalent to one positive node.

I am ten years out knock on wood.

Breast Cancer Index folks told me they were changing their classification of risk. At 5.7 % I was "high risk" on the BCI, but this was the same as Oncotype's "low risk" at 6%!

Jump to this post

Congratulations - 10 years a long time!
I have never read or been told that lymphovascular was equivalent to one positive lymph node.
Where you nodes biopsied?
Did oncologist tell you this?
I also had a high ki 67 of 20% with onco score of 4.
Such

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