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← Return to Orgovyx as lifelong treatment
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Yes. Still castrate-sensitive after 3 years 4 months (PSA < 0.01). The TITAN study showed that Apalutamide used together with ADT can delay castrate resistance for mCSPC dramatically compared to pairing with earlier 1st-gen ARSIs (many TITAN participants were still castrate-sensitive at the end of the 4½ year study), and I'm fortunate that I was diagnosed just as Apalutamide became widely available in Canada, so I got the full benefit. The other -lutamides are also very effective (some perhaps even more so).
What's it like on ADT in the long term? Well, you do get used to it. And Orgovyx is *far* easier than the monthly Firmagon injections that I started with. I miss my hairy chest and don't love the gynecomastia that has replaced it, but I do love that I'm not counting down my last months yet.
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❝Still castrate-sensitive after 3 years 4 months (PSA < 0.01).❞
I forgot about this old post. Just a couple of weeks left until now until my 4-year cancer-versary.
I am so grateful that I landed at a decent Ontario Cancer Centre that was up-to-date on the latest research. Doublet care and radiating the primary and all metastases wasn't yet widespread standard of care of oligometastatic prostate cancer in 2021 — heck, Apalutamide wasn't even in the Ontario formulary yet (my onco team got special permission for me from the provincial Ministry of Health). I had expected to be very sick or dead by the 4-year point, and instead, thanks to quick, aggressive, and (then) cutting-edge treatment, I'm going strong. I'll meet my first grandchild in January, something I thought in 2021 (at age 56) I'd have no chance of living to see.
Don't give up hope, friends, even when you feel like you've just heard your doom from the onco team. Today's survival stats are based on yesterday's data; we're the cohort writing tomorrow's. ❤️
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Yes I agree it is better than(for me) the 3 month Lupron shots. I have been solely on Orgovyx for 5 years now. I’ve just adapted to my new “normal” with fatigue and all the accompanying side effects.