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Looking for input on 2nd opinion after 3 years of Alendronate

Osteoporosis & Bone Health | Last Active: Jan 31 12:13pm | Replies (29)
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@windyshores

I could not tolerate Forteo, which delayed my osteoporosis treatment for a few years, until Tymlos became available. On Tymlos, my spine went from -3.7 to -2.5 and my hip from -3.3 to -2.9.

I plan on asking my doctor about the dosage differences between Forteo and Tymlos. Forteo is a parathyroid hormone and Tymlos is a parathyroid protein, so I wonder if Forteo's action is more direct and therefore the dosage is lower. Does anyone have info on this? Of course, the Tymlos dose is adjustable but some may take 1/2 to mimic Forteo dosage and it would be good to know if that is a valid choice.

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Replies to "I could not tolerate Forteo, which delayed my osteoporosis treatment for a few years, until Tymlos..."
oopsiedaisy | @oopsiedaisy | Jan 27 3:12pm

Teriparatide (T) results in prolonged (longer) signaling of the cAMP pathway while Abaloparatide (A) is transient (shorter). The research paper linked below explains that this is related to how each bind to the parathyroid hormone type 1 receptor which has two conformations (R0 and RG). T has a greater affinity to the R0 conformation which results in prolonged signaling while A has a greater affinity to the RG conformation which results in shorter signaling.

The paper also explains that this accounts for the lower risk of hypercalcemia and less bone resorption signaling seen with A.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9586930/

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bktexas | @bktexas | Jan 31 12:36am

Sounds like Tymlos really did work well for you! Can you plz tell me if you had any of the side effects they mention as to Tymlos? Did you experience feeling bad for hours after an injection? I am personally torn as to whether to take Tymlos or Evenity. I do prefer to take on injection once month vs daily. Sorry, cannot recall what my numbers are currently. I just know that my endocronologist said I need to get on something asap. I have been on Fosmax for about 12 months. Fortunately, I have never had a fracture! My dr is shocked about that!
Can you comment on which is better, Tymlos or Evenity?
So happy your numbers were so improved. That too is my goal.

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