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C-Diff help

Digestive Health | Last Active: 3 days ago | Replies (8)

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@hardingv

I also failed vancomycin (including a long taper) and difficid with repeat occurrences of c diff.

I was temporarily in Texas going to a GI at Houston Methodist when I had a severe case following a hip replacement. In discussing in summer 2022 what to do if there was another recurrence, that GI was going to use Zinplava. She said she didn't think anyone at HM was doing fecal matter transplants (FMT) because the banks of Fecal matter were pretty much shut down during covid.

But when I returned to AZ and discussed this with my Mayo GI in Oct 2022, he dismissed Zinplava and reiterated advice I was given in 2020 to use a FMT. I had a total procto-colectomy in 2023, so from my perspective the issue became academic.

However the current Mayo web site includes discussion of FMT as a treatment (9/2013 page date) with a link to a video (5/2016 page date) that references the criterion 3 c diff occurrences that did not respond to regular treatment as one option.

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C. difficile infection - Diagnosis and treatment - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/c-difficile/diagnosis-treatment/drc-20351697
Fecal transplant treatment of C. difficile at Mayo Clinic - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/c-difficile/multimedia/c-difficile-treatment-fecal-transplant-video/vid-20203002
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In checking further I found that the American Gastroenterological Association (AGA) issued guidelines in 2024 that are probably the source of comments noted above about criteria for FMT.

Note that they distinguish between patients who are not immunocompromised, those who are mildly or moderately immunocompromised, and those who are severely compromised

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AGA Clinical Practice Guideline on Fecal Microbiota–Based Therapies for Select Gastrointestinal Diseases - Gastroenterology
https://www.gastrojournal.org/article/S0016-5085(24)00041-6/fulltext
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It seems to me that a FMT is worth checking out and the first step is to find GIs/medical groups who perform any FMTs. Then check what criteria they use and what it takes to qualify.

Good luck in finding a solution. C diff is a nasty disease.

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Replies to "I also failed vancomycin (including a long taper) and difficid with repeat occurrences of c diff...."

Thank you for the helpful info. My local GI doesn’t reference any criteria except bloodwork. I have autoimmune disorders and other health conditions that may qualify me for the transplant in addition to exhausting all known antibiotics. I’m waiting to hear from Mayo to set up an apt praying they will be able to offer new options and relief including the FMT but also confirming if there is something else going on causing it not to heal. I really appreciate the help!