Dang, @llynch17056 I am sorry you have experience to know just how bad side effects can be. I feel your pain! Only you knows what pain fits with that net-positive. I do not have negative side effects from Inclisiran. I did have one rough night after shot #1, then a bit less of a rough night a couple days after shot #2. Related? IDK My doctor walked through that with me and here we are. They dug into details of lipid (APOB APOA, etc) and inflammation markers (ceramides, etc) to learn just where I fit in compared to the norm (my words, not theirs). What is your doctor recommending?