But that's almost a 50% reduction, et1055!

Congratulations, especially since your initial count was so high.

For me (with the very stubborn MPL driver), it took 14 months of HU to get from the high 700s to 505.

I'm grateful my oncologist considers 505 acceptable, and that his incremental dosing meant no side effects from HU.

Mine were in 800 and went to 600s in a year if HU 500 mg/day. Dose was upped to an extra cap 3 × per week and now in the 400s, where it has stayed for past 5 years. Results can be slow for some of us. Don't lose heart.

Mine were similar levels but it took longer. My doc is ok with me around 600 as am I. I didn’t like my neutrophils being so low when my HU was increased. Now they are in a good range
I take 1000 m-f and 500 on S/S. And bbasprin