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What are most common side effects when starting HU (Hydroxyurea)?

Blood Cancers & Disorders | Last Active: 1 day ago | Replies (113)
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@liesel

I have been taking HU 500 mg daily for a month, and platelets went down from 800,000's to 5oo,oo's, which is good. My problem is extreme fatigue. I have always been very active, and now I get to half way through the day and I'm exhausted. I don't know if that's from the ET or the HU.

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Replies to "I have been taking HU 500 mg daily for a month, and platelets went down from..."
janemc | @janemc | 4 days ago

Congratulations on your success!

We are all different, but for many of us, once HU tamps down ET's manic overproduction of platelets, we gradually get our energy back.

Hope you will experience that too!

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mdterp76 | @mdterp76 | 2 days ago

Is your doctor doing blood studies about iron? I had similar numbers to yours although I take HU 4x week. I also take iron supplements 1x day which improved my energy level. I have low iron but not anemic. The fatigue got better for me after being on HU for a year. My doctor does incremental dosing and started low and worked up to 4x week with HU. I also drink a lot of water as the HU makes me very thirsty. Hydration is good for the energy too. Take care!
Karla

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