@bayhorse you can also look up the FRAME and ARCH studies. There was no difference in cardiovascular issues (including heart attack and stroke) between Evenity and placebo, but a small but statistically significant difference with alendronate. Articles propose that the latter result may be because alendronate is slightly protective.

Your endocrinologist's opinion seems unusual since I have talked to two endos and two cardiologists about Evenity with full go ahead and they are all in a top hospital system.

I can only repeat what my doctors tell me. They do not use Prolia unless absolutely necessary, due to the rebound when stopped. They do use Evenity, Forteo, Tymlos and bisphosphonates.

As for my unusual reactions, yes I have a systemic lupus diagnosis and very high antibodies for scleroderma. I react to foods, meds and scents. That said, doing the shots in my thighs seemed to help. Evenity has polysorbate 20 (not polyethylene glycol as I posted elsewhere, but chemically related). I would do Evenity again. My friends have done amazingly on it.