@rmoore901 , I too take the big 3, 3 days/week. On those 3 days I take: Rifampin- 2 per day, Azithromycin- 1/day, Ethambutol- 2/day.
I take my first Rifampin at 7am, after fasting all night, then I eat breakfast at 8am.
I take Azith. after breakfast. I take my first Ethambutol after lunch, probiotic in afternoon,
last Ethambutol after dinner, stop eating, then take my last Rifampin at bedtime.

My only side effect is I have, sometimes sever, lower abdominal cramps. Sometimes it helps to go to the bathroom and sometimes taking Dicyclomine helps. My IFD doctor shocked me when I complained to her about these cramps and she said she'd never had anyone complain of that before, but it's on the RX side effect description! Does anyone else suffer from lower cramping from the antibiotics? I don't cramp on non-medicine days.