@cdurbin I, too, have PV and was diagnosed 5 years ago. I take 2 baby aspirin/day and undergo periodic phlebotomies to keep my Hematocrit under 45. I have about 3-4 phlebotomies/year. I consult w/Dr Tefferi at the Mayo Clinic via video visits once/year. I tell you this because Dr. Tefferi, who is a Hematologist, has written many publications on the topic of PV. I am a low risk patient like you. He believes in targeting the hematocrit and not focusing on the platelet count. My platelets vary and can be as high as 700,000. He doesn’t care. I would suggest that you read some of his scientific articles and perhaps schedule a video call with him to discuss your case. He has never advised that I take HU. Here is one of his articles. I hope this helps. Good luck, Andrea
https://onlinelibrary.wiley.com/doi/full/10.1002/ajh.27002