I take ~3 grams of bioavailable curcumin/day for MGUS. Bioavailable means it has peperine (found in black pepper) and/or lipid (fat) that helps absorption, because otherwise curcumin is very poorly absorbed. Don't know if it helps; the curve of my Kappa proteins has flattened a bit, but that could be other. There is research now on the curcumin, how it affects TNF (tumor necrosis factor), and if there are modifications to the curcumin that could increase absorption and effects on TNF.