Tips on minimizing withdrawal symptoms from Effexor (aka Venlafaxine)

20 years on this drug. I have quit cold turkey and oh my lord. This is hell, the feelings I would get if I just missed a dose. Wow. This IS HELL . I just want to die it hurts so bad. Everything is firing inside my head. Oh why did I ever allow this to happen.

Hello, @hezz -- welcome to Mayo Clinic Connect. I'm pretty confident this is the discussion you'd wanted to locate.

I'd encourage you to look back through this discussion for some of the experiences of others who've faced some of the same very tough withdrawal symptoms coming off venlafaxine (Effexor). I think members here like @gailb, @stressedmesseddepressed, @lisabee, @panewdayphyl @vdandy @lukekee @sadiesmom @jimhd may have some thoughts for you as you are trying to manage these symptoms.

@hezz -- sounds like you have quite a bit of responsibilities taking care of others at home now. Do you have friends or other relatives who could provide some support for you as you go through this process of coming off venlafaxine (Effexor)?

Hi there! I am new to Connect, but hopefully can offer some insight. I DID go off 150 Effexor XR (name brand) COLD TURKEY on January 2016. I survived it, but will never in my life EVER go off ANY antidepressant cold turkey. I had taken Effexor for at least 8 years, Zoloft prior to that and and Imipramine (sp?) as the first antidepressant (in all 25+ years on antidepressants.) It all started with running out of meds over a long weekend and deciding it was time to try to get off antidepressants to see how I would do. Since I had recently retired from teaching, thought this would be an ideal time to give it a go. In addition, Effexor just wasn't helping all that much anymore (I thought.) The first 3 days I felt like I was going to die! When I realized that I wasn't dying, decided to keep going to get it all over with. In addition to the symptoms you have heard about, I had deep bone/joint pain that felt like I was being pinched with clamps. Also had skin sensations and peeling, and noticed a strange smell on my skin. Each day got a little better and by the 3rd week started to function a bit more normally. I was very emotional, however, which caused my family great concern. Well, to make a long story short, the depression crept back in full and I am still trying to get my life back. I did everything I could to stay stable, including herbal supplements and took a vacation where I hiked 6 miles daily for 9 days on hilly, rocky terrain. I finally had to accept that I'm a person who will need antidepressants for the rest of my life. With the help of a PCP and counselor, I am on my 3rd antidepressant & may need to resort to going back on Effexor, because nothing seems to be working. All in all, in my opinion, the chronic depression is worse than the withdrawal symptoms that do eventually end. If you are a person with situational depression, you may be successful weaning off Effexor gradually. If I were to do it again, that's what I would do (while replacing Effexor with something else.) Here are the things that helped me with the physical withdrawal symptoms:
1. Get plenty of sleep/rest.
2. Eat a very well-balanced diet (this is not the time to worry about your weight.) Lots of soup & easy to digest foods the 1st few days.
3. Drink plenty of water, including coconut water.
4. Have a glass of wine in the evening (if advisable.)
5. Get outside and walk or other excersize (the warm sunshine will feel good!)
6. Hot yoga 3-4 times per week. Stay in class even if you feel nauseous & can only do a few postures.
7. Soak in a hot tub (with bath salts if available.)
8. Use a good moisturizer on face & body several times per day.
9. Get several professional massages.
10. Take Tylenol for muscle pain, if OK on your stomach.
11. A heating pad is also helpful at bedtime or during naps.
12. If you are single & live alone, make sure a few trusted friends/family members know what you are doing.
13. In general, be kind & gentle to yourself.
14. NEVER give up! Keep going, even when you don't feel like it (which will be often.) YOU ARE WORTH IT!!!

My bad test results a month ago indicated that my liver was suffering damage from medication and was triggering autoimmune hepatitis. I've been reducing my medications ever since. I take a series of supplements and vitamins to help me get off the 375mg Effexor XR I've been taking for 12 years. I would recommend that anyone following this protocol take the supplements and vitamins for a month before trying to reduce your Effexor; also, make sure you are doing so under a doctor's supervision in case there are any reactions to the supplements. Lastly, this protocol has helped me avoid any physical symptoms of withdrawal. It is important to be aware of emotional symptoms when coming off antidepressants. If you start having intense emotional symptoms, contact your doctor immediately.

I have been reducing my Effexor by 75mg every 4-5days. It has always been beneficial for me to split my dose throughout the day. In other words, if I am taking 300mg, I take 150mg morning and night to keep the dose steady throughout the day. Now that I am taking 37.5mg, I am taking the dose only in the morning. I have only a few more days at 37.5mg before I come off the drug completely. I am also following the Paleo diet (recommended by my doctor for the autoimmune hepatitis) and exercise with cardio and weight training 4-5 times per week.

This is my daily medication protocol as of today:
Morning (taken first thing in the morning without food)
1 cap Vitamin D3 1000 UI
1 cap L-Tyrosine 750mg (to boost dopamine production in the brain)
2 cap probiotics (I take Dr. Tobias Deep Immune Probiotics, 4.4 billion)
1 cap Vitamin B6 100mg (to assist the L-Tyrosine)
1 cap Effexor 37.5mg

Night (taken at least one hour before bedtime)
1 cap L-Tryptophan 500mg (to boost serotonin production in the brain)
2 cap Omega 3 Fish Oil (I take Dr. Tobias Omega 3 2000mg Fish Oil w/ 1400mg Omega 3s - 800mg EPA, 600mg DHA)
2 cap Choline/Inositol 500mg/500mg (more a supplement for my Paleo diet, but I wanted to include it here as well)
1 cap Viatmin B6 100mg (to assist the L-Tryptophan)
1 cap multivitamin (I take Centrum Woman as it contains iodine for healthy thyroid support)

To assist with any anxiety, I have a prescription for 25mg Seroquel to use on an as-needed basis. I have only been needing the Seroquel rarely but when I do take it, I take it right before bedtime. I purchased all the supplements and vitamins from Amazon as they had the best selection and fastest shipping. I hope this information is helpful. I came up with this list through research into reducing Effexor and looking at supplements that can help boost neurotransmitters in the brain. If there are any questions about this series of supplements that I am taking, please message me or reply and let me know. Thanks.

20 years on this drug. I have quit cold turkey and oh my lord. This is hell, the feelings I would get if I just missed a dose. Wow. This IS HELL . I just want to die it hurts so bad. Everything is firing inside my head. Oh why did I ever allow this to happen.

Hi there! I am new to Connect, but hopefully can offer some insight. I DID go off 150 Effexor XR (name brand) COLD TURKEY on January 2016. I survived it, but will never in my life EVER go off ANY antidepressant cold turkey. I had taken Effexor for at least 8 years, Zoloft prior to that and and Imipramine (sp?) as the first antidepressant (in all 25+ years on antidepressants.) It all started with running out of meds over a long weekend and deciding it was time to try to get off antidepressants to see how I would do. Since I had recently retired from teaching, thought this would be an ideal time to give it a go. In addition, Effexor just wasn't helping all that much anymore (I thought.) The first 3 days I felt like I was going to die! When I realized that I wasn't dying, decided to keep going to get it all over with. In addition to the symptoms you have heard about, I had deep bone/joint pain that felt like I was being pinched with clamps. Also had skin sensations and peeling, and noticed a strange smell on my skin. Each day got a little better and by the 3rd week started to function a bit more normally. I was very emotional, however, which caused my family great concern. Well, to make a long story short, the depression crept back in full and I am still trying to get my life back. I did everything I could to stay stable, including herbal supplements and took a vacation where I hiked 6 miles daily for 9 days on hilly, rocky terrain. I finally had to accept that I'm a person who will need antidepressants for the rest of my life. With the help of a PCP and counselor, I am on my 3rd antidepressant & may need to resort to going back on Effexor, because nothing seems to be working. All in all, in my opinion, the chronic depression is worse than the withdrawal symptoms that do eventually end. If you are a person with situational depression, you may be successful weaning off Effexor gradually. If I were to do it again, that's what I would do (while replacing Effexor with something else.) Here are the things that helped me with the physical withdrawal symptoms:
1. Get plenty of sleep/rest.
2. Eat a very well-balanced diet (this is not the time to worry about your weight.) Lots of soup & easy to digest foods the 1st few days.
3. Drink plenty of water, including coconut water.
4. Have a glass of wine in the evening (if advisable.)
5. Get outside and walk or other excersize (the warm sunshine will feel good!)
6. Hot yoga 3-4 times per week. Stay in class even if you feel nauseous & can only do a few postures.
7. Soak in a hot tub (with bath salts if available.)
8. Use a good moisturizer on face & body several times per day.
9. Get several professional massages.
10. Take Tylenol for muscle pain, if OK on your stomach.
11. A heating pad is also helpful at bedtime or during naps.
12. If you are single & live alone, make sure a few trusted friends/family members know what you are doing.
13. In general, be kind & gentle to yourself.
14. NEVER give up! Keep going, even when you don't feel like it (which will be often.) YOU ARE WORTH IT!!!

Hello, I am Bright Wings. I too am withdrawing from Effexor. I have taken this med for 26 years. I came here last Friday and read this thread for 4 hours. I can not tell you how much doing all this reading helped me.
My symptoms of withdrawal include severe vomiting, sweaty palms, (to the point of being able to make a palm print on a paper towel from just the sweat on my hands.) Body shaking, total body shivers, sweating bullet size rolls of sweat rolling down my forehead. Also, difficulty sleeping and severe loss of energy. There are so many more but can't access that information this minute because I miss my brain after a stroke. Oh I am fine so don't worry about that.
I do have some solutions for the symptoms and will post them when I get back from walking my dog.
Every spring for so many years I have worked to get off this drug. This time I am succeeding. Yea.