Hi, I am 48 & was diagnosed last year with ET- JAK12 positive. My hematologist at first started me on the Hydroxyurea but I broke out in rash for 3 days before they decided to have me stop it. I am considered low risk due to never having blood clots or other issues other than elevated platelets. Mine for now are treated with a baby Aspirin. I also started taking vitamin D after doing some research to naturally lower them. I read that vitamin D has an affect on lowering platelets. It could be just a fluke but I get labs every 3 months & my last levels were 623. I know the levels fluctuate but I have had other levels in the 600 range as well so I feel like something I'm doing is helping. My highest levels since my diagnosis was 780 something. I go for my next labs in April. Hopefully your doctor will hold off on the Hydroxyurea if possible. My doctor told me it just helps with lowering the platelets so that is why she was comfortable with taking me off it for now. If something changes & they start going up we will revisit my meds.