Neuropathy associated with Mounjaro use

Hello,
I started Mounjaro 2.5 the week of new years 2025. Within a day of the 1st dose, I had restless sleep, muscle spasms, pins and needless in hands and feet and numbness in both hands and feet. At first I was thinking it was my pillow so I bought 3 different ones and flipped my mattress. But it was getting worse. I was thinking part was from my herniated disc's and my distal bicep tendon tear. But these symptoms just didn't add up to the occasional nerve compression pain i experienced before. This was absolutely continuous. I also noticed on my normal daily routines my muscles were so weak and tired. I had to take a lot of breaks. The day before my 2 injection, called my Dr and because neuropathy pain was not on any documentation he wanted me to take a second dose and see if everything subsides. It didn't. The pain only got worse and the exhaustion set in from lack of sleep. I called my doctor prior to the 3rd dose to give and update. I had not heard back and Due to my sugar levels I reluctantly took a 3rd dose. I called his office again and I refuse to take my last dose. I can't do it anymore. I'm hoping to not only share my story, shed light on a side effect but I'm also hoping to get answers as of reprieve status. It's only been 1 day but I am hoping it subsides.

Sorry you are experiencing this. I hope you get better. I worry how many other side effects will surface with this relatively new "wonder" drug.

I have been on mounjaro 5 mg and 7.5 mg for over a year for insulin resistance/diabetes. I have started last April 2023 with weakness/tingling/joint pain from waist down. I have been to numerous doctors from neurologist, rheumatologist, orthopedic doctor and had many tests done to get proper diagnosis to no avail. I have financial decided to stop mounjaro 3 weeks ago and today first time in months my severe leg pain and weakness feels much better. I am able to walk without needing to rest every few steps. Still very stiff but without severe, burning and achy legs. I am still in shock that this could be mounjaro.

HI. YES! But NO! LOL I would'nt call it nueropthay however, i do have the muscle soreness, the joint soreness, the headache, the dry mouth and that tingling feeling on my skin. My body gets so sore, i can barely function, I have googled but your right, no one has recognized it other than some REDDIT postings where others have experienced the same.

Had peripheral neuropathy 2 months after starting Mounjaro 2.5mg. Thought it was due to Vitamin B deficiency due to decreased meat protein intake secondary to nausea. Stopped medication, and it resolved. Began taking tirzepitide, and within 12 hrs on initial injection, had intermittent neuropathy again. It was tolerable though. Once dose reached 10mg, significant widespread neuropathy followed within hrs of injection. This increased neuropathy occurred with no recent weight loss.

Are you saying Mounjaro is causing neuropathy? Did you check that with your doctor?

Did you report this to the FDA? I believe one of the people earlier in this thread provided a link to the form to use. Patients can do this -- doesn't have to be a doctor.

Just to add: this is the way we discover side effects that are not common, but still real and important. If we find that our PN correlates with dosage changes of a drug, or with starting and stopping a drug, we get to contribute to science and drug development if we report this to the FDA -- they won't explore it if no one knows it is happening.

And let's face it, these drugs are sledge hammers. GLP-1 serves tons of purposes in the body, and therefore positive and negative side effects are inevitable, many of which will either not emerge in clinical trials, or are not being looked for or lost in the noise.

So bravo to everyone for noticing these correlations, and please report your personal experience to the FDA.

In my case, I'm no longer convinced that the source of my problem is the GLP-1 RA -- pretty sure it was a coincidence of timing, since it doesn't seem to change with dosage, and avoiding B6 supplementation seems to have correlated more strongly. Having said that, I have not tried stopping the GLP-1 RA altogether. That would be the real test, but the PN is not bad enough to drive me there.

I had and still have PN. I stumbled across B6 toxicity as a PN cause (B6 deficiency is also a problem and deficiency is often prescribed when toxicity is the problem, as the symptoms are the same). Had the blood test and yes - very high B6.
Serum levels dropped to normal in about 5 weeks.
On going blood tests every month.

Severe increase in neuropathy symptoms during detox of B6.

Tiny amounts of B6 (10mg) after levels returned to normal aided brain fog. Still on the road to recovery from the nerve damage.

Water, exercise, low dose ALA and ALC, magnesium and B12 is my current regimen.

Oct 2024 the same thing happened to me !!! My face is numb and hands and feet are horribly numb and burn. Finally got in with a neuro Dr and he said MS. I had to stop my shot for surgery and numbness was gone, took it again and I could literally feel it creeping back. Appointment in a few weeks to speak to the Dr about it.