1. < Prostate Cancer

Lupron: Anyone have muscle weakness and severe leg pain?

Posted by kam23 @kam23, Jul 14, 2023

I have PC and have been on Lupron injections every 3 months for 15 months. I am experiencing severe leg pain in hamstrings and glutes. Has anyone else experienced this or tried monthly shots?

This has been getting worse for the last 3-4 weeks. I’m afraid I’ll be in a wheelchair or have to stop this form of testosterone elimination therapy.

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narus | @narus | 1 day ago
In reply to @keithrichard "65 yo male, Brac 1 positive w/ breast cancer & mild prostate cancer. Have endured monthly..." + (show)
@keithrichard

65 yo male, Brac 1 positive w/ breast cancer & mild prostate cancer. Have endured monthly Lupron shots for 6 mo. while taking anastrozole daily. Also developed L4-L5 spinal stenois and osteoarthritis in both hips and knees. 5cm breast tumor shrinking but with every Lupron shot groin & thigh pain getting worse and worse. Very sexually active before Lupron and know not in 5 months. On a walker 95% percent of time and cane the remainder. I'm still working full time and quality of life is dismal. No pain or discomfort from cancer but leg and hip pain very debilitating. Considering going against Dr. and stopping Lupron & anastrozole after tumor removal scheduled for February 2025. Dr. had suggested Lupron for another 5-10 years after surgery. No way.

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I would not stop the Anastrozole which lowers estrogen and is given to woman at risk for breast cancer. I take Anastrozole, Amour Thyroid and Clomid for low testosterone. The Lupron lowers your testorone to near zero and this is what is responsible for the way you feel. Have you had radiation for the prostate cancer or is it so mild they chose to treat it with Lupron.
You must at least have good insurance because the Lupron shots are like $5k
Five years on Lupron is crazy.

REPLY
alrunner | @alrunner | 1 day ago

I was a pretty good marathon with decent speed running 30-40 miles a week. Received a Lupron injection 6 months ago and completed Proton radiation 4 months ago. PSA is was tested 2 days ago and is undetectable. For past 2 months I have been dealing with leg pain during runs staring in mile 2 or so. Legs feel like mile 30 of a marathon with so much discomfort I only managed 4 slow painful miles today. Doctors don’t give me a definitive answer.

I know I am lucky to be out there but can anyone tell me of similar experience and if you ever got past the leg pain. This only happens when I run.

Of course I have other side effects like hot flashes.

Thank you
Al runner

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