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Support For Those Quitting Prolia

Osteoporosis & Bone Health | Last Active: 1 hour ago | Replies (158)
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@windyshores

I believe that Keith McCormick said that a CTX under 100 is actually too low, and that micro fractures don't heal with that level of turnover. Maybe someone else can confirm. My CTX was 145 which my endo said showed sufficient suppression of resorption. Is it possible that you have too much suppression of turnover? Can you ask your doctor what the optimal CTX would be in your situation?

Your spine DEXA is excellent so the "mild fracture" is strange. Can you get it checked out further, with an MRI? I have no idea if that would be useful.

Prolia itself can cause fractures due to the suppression of turnover, usually after many years, and we are told that the risk is for atypical femur fracture and jaw necrosis.

Can you ask your doctor if the rise in fracture risk with Prolia rebound is independent of the CTX? Or if Prolia itself can cause fractures?

Hoping it is an x-ray artifact! Your DEXA for spine is so good.....

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formisc | @formisc | 4 hours ago

Thank you for your thoughts and comments, windyshores. I had wondered about the low CTX myself but felt i didn't have much choice but to carry on with the Alendronate for at least a year to prevent any Prolia rebound. I have only read about long-term use of Prolia possibly causing MVFs or ATFs but not normal spinal compression fractures so I don't know if Prolia (or Alendronate) itself could be the cause. It is also probably unlikely to be caused by Prolia rebound as the indication there would be very high CTX.

My immediate decision now is whether i should stop my Alendronate now (after having completed 1 year since the skipped Prolia shot) to allow CTX to rise to assist in healing? Unfortunately, my PCP has little knowledge about osteoporosis treatment - he started me on Prolia without any calcium or D3 tests or taking any baseline numbers and he didn't know about the Prolia rebound danger.

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