Hello @mbi . Back on July 17 the same question was posted to the related conversation "Does Camzyos reduce thickening of the heart or manage symptoms?" My response (pasted in below since I don't know how to link directly to that message), says that **IN MY NON-MEDICAL OPINION** it kind depends on how you define your terms. Whether I have interpreted the question or the actual medical information correctly, I suggest you check the video at the camzyos website (https://www.camzyos.com/resources#video1). It was very helpful to me. And regardless where you go on your HCM journey - Best wishes!

Message from related conversation:
Hi @haasil and welcome to the family. I hope folks here can help answer your question. This support group has been an amazing support for me. I assume you probably found the video https://www.camzyos.com/resources#video1 but in case you haven't, I recommend it. But first, I am no expert - I'm just an idiot who watched a video. So take everything that follows with that in mind.... The way I understand it, Camzyos doesn't actually cause any structural changes to your heart (thinning out the the thickened muscle), but it also doesn't really just treat/mask the symptoms either. Rather, it affects how the compounds myosin and actin interact with each other to help your heart contract and relax better. So while the Camzyos is in your body, it helps the heart pump better DESPITE the thickened muscles. But if you go off Camzyos, (when the last traces are washed out of your body), things go back to the way they were - same thickened muscles as always, but back to the old impaired contract-relax cycle. Now that being said, I'm defining "symptoms" as "the things I feel." But if you define "symptoms" as "the things I feel AND the numbers that show up on an echocardiogram" (see the post from @andyherman3), then YES, Camzyos is working on the symptoms. But again, not just by masking them. Did that make sense? It made perfect sense in my head, and I hope it translated properly. For what it's worth, I was lucky enough to be eligible for Camzyos, and that it worked immediately and amazing well for me. 17 years of debilitating symptoms 100% gone in under 2 weeks. Whatever you elect to do, I wish you good fortune!