reaction from LD Naltrexone

Posted by sailorswimmers @sailorsrwinners, Sep 2, 2024

I started taking Low dose Naltrexone in early July compounded to 4.5mg, the dose that helped relieve some of my fatigue. However, now I have very annoying skin itching in various places (hands, ankles upper torso, upper arms). I also have a rash under my breasts and on my upper back. I intend to discontinue the LDN for awhile even though it has helped my fatigue. Has anyone experienced this kind of reaction to LDN? And is this a common side effect?

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mariejoseph | @mariejoseph | Jan 14 9:11pm

Husband with LC has worked up to 4.5 mg Naltrone (compounded) He can’t tell if it helps.

mariejoseph | @mariejoseph | Jan 14 9:11pm

In reply to @mariejoseph "Husband with LC has worked up to 4.5 mg Naltrone (compounded) He can’t tell if it..." + (show)

I meant Naltrexone,

Lucy | @welchllb | Jan 15 8:09am

I just started LDN - 4 weeks in and have not had an adverse reaction to-date. I understand that it doesn't really take effect to alleviate symptoms until you've been on it for 3 - 4 months. I've got my fingers crossed!!

sailorswimmers | @sailorsrwinners | Jan 15 8:34am

I developed a very itchy rash on y chest after compounding to 4.5 mg LD Naltrexone. I discontinued the Naltrexone and the rash eventually faded. It had faded by the time I got an appointment with a dermatologist. So she couldn't identify it in any way. Now I restarted the Naltrexone and are about to start taking 4.5mg. I guess we'll soon see whether I get the same rash.

itchee | @itchee | Feb 9 5:51pm

I've been on 1.5 for just over a week and have had bad rash on legs and arms. I thought it was from the sun but I never had issues before. Thought maybe more sensitive with new medication. It eased for awhile but still irritating. I up to 3 this week. Gonna try but wondering if LDN is causing this.

sailorswimmers | @sailorsrwinners | Feb 10 7:53am

In reply to @itchee "I've been on 1.5 for just over a week and have had bad rash on legs..." + (show)

My rash lasted for several months even after discontinuing Naltrexone. By the time I could get an appointment the rash had faded and the dermatologist could not identify its cause. I have restarted the Naltrexone and a up to 4.5 where I will stay. No rash yet!!

itchee | @itchee | Feb 10 2:10pm

In reply to @sailorsrwinners "My rash lasted for several months even after discontinuing Naltrexone. By the time I could get..." + (show)

Good to hear. I have an appt with mine in a couple of weeks after I increase to 3 mg. I had a similar rash last year and Dr said it might be a lotion. I changed and it seemed to work but wasn't on LDN then. It's not super horrible so I'm gonna keep using to see if it gets better after I up my dose this week. I know the sun really seems to hurt just being in it for a minute so might be a connection there to something I'm taking.