Yes to heart transplant & Tac. He was only on Mycophenolate a couple months. They stopped that 1 as his heart biopsies were +2 rejection. They upped his Tac instead. After a year or so docs lowered the Tac back to 3 mg from 4. He will be 12 years out in May & it’s been a nightmare. He had Rt. Mid cerebral artery stroke in recovery, so lots of on going issues with that. Sees Dermatologist 4-6 Wk intervals. Always has squamous carcinomas. Lots of Mohs & freezing. He was put on Rapamune with goal to quit Tac. It has a lower cancer profile. As he was building up, he was still on Tac, reducing weekly. Couldn’t get through it as the 2 drugs together even for a few weeks, caused dangerous bleeding episodes. Building new, while reducing old. I hope for u that if your doc decides to try a different drug there is a better way to transition. I wish you the very best with your Kidney & any Medicines that could reduce cancers. Keep me posted.