I have previously researched & looked at feedback from multiple sources. It is clear people react very differently as individuals. Both in how high an mg dose of Anti-depressant they can tolerate. And , how quickly they can then titrate off of them. It seem that , as with me & effexor / Venlafaxine, dropping down from 75 mg to 37.5 mg can be done by many people in quite a short timeline. BUT, it is commonplace that then dropping down from 37.5 to 0, has to be done MUCH more slowly. I have seen many cases reported, where withdrawal symptoms get much more severe, post the 37.5 mg dose. Having said that, I am in the lowish % of people that are hyper sensitive to ANY Anti-depressant. So, the hyper slow dropping down from 37.5 took a long time to be able for me to cope with the withdrawal side effects, at each stage of reduction. At the extreme opposite, Some people can stop & start taking any Anti-depressants at will, with very little adverse effects.

The Maudsley Deprescribing Guidelines explains why smaller doses are more difficult to stop, and why you must proceed slowly. It has to do with a "hyperbolic taper." To simplify, picture this: Dropping 10mg from 300mg is a small change, but dropping 10mg from 37.5mg is a huge difference. Thus, the smaller the dosage, the smaller the change that must be made in order for your brain to have time to adapt to that drop. Hope that makes sense.