The facial rash is treated proactively with doxycycline and an acne gel applied twice a day. My understanding is that different participants have different levels of severity. Mine was pretty severe to start but after the first two cycles really moderated. Unfortunately, the doxycycline can also be hard on your stomach. My appetite has been modestly suppressed, I eat more frequent, smaller meals. I have only lost a couple pounds since being in the trial. My only nausea has happened when I eat too much too fast. They do prescribe Kytril for nausea. My understanding is that other participants may have had more challenges with nausea. If she is accepted in the trial, there is a Facebook chat group for trial participants that has been helpful to share information. I assume she is KRAS G12D positive. You may want to check out the Facebook Group “KRAS Kickers” and “KRAS G12D Kickers”. Lots of good information being shared across multiple cancer types with the KRAS mutation.