Biologics side affects

Hi I have crohns/colitis I was on Entyvio too but came off it bad side effects as well. I had constant headache especially with light or the sunshine I had to wear sunglasses all the time.One of my eye's was red like bloodshot and progressed worse as time went on.I went to hospital and they said it was uveitis it can come with crohns as it's autoimmune. I am still getting flair ups using steroids in my eye to clear it.I never had uveitis before I went on entyvio I think it's a side effect I am left with. I am waiting to start a new biologic now I'm not having much luck with any at the moment I have been on a good few.Humira,remicade, the only thing that seems to be working for me is steroids unfortunately.

I didn’t treat my spondylitis for about eight years; one, I had a scare with CMV and hospital stay; and two, my Rheumatologist retired and finding a new one that would accept his diagnosis was nil. Now I am paying for it with full spinal damage. Even though the methotrexate and hydroxychloroquine have my inflammatory numbers completely down I hurt from the damage done those years. I hope you can find something that will work for you and slow the progression.

I'm in the same boat. I was diagnosed with spondylitis about 30 years ago. I also had an aggressive type of uveitis along with spondylitis. My ophthalmologist treated the uveitis aggressively with high dose prednisone whenever it flared. I always had leftover prednisone on hand to treat the pain caused by flares of reactive arthritis.

I never saw a rheumatologist until 15 years ago when I was diagnosed with PMR in addition to spondylitis. I needed to take about 40 mg of prednisone daily for the first few years to keep all my autoimmune conditions quiet.

About 4 years ago when I was unable to taper off prednisone, a biologic called Actemra (tocilizumab) was tried. I was then able to taper off prednisone and now everything is being managed with Actemra. I have taken Actemra for 4 years and haven't had any serious side effects while taking Actemra.

Prednisone managed the pain reasonably well. Unfortunately, prednisone didn't prevent the inflammatory damage. My lumbar spine is now a disaster zone. I'm seeing a neurosurgeon tomorrow to discuss a lumbar fusion. The surgeon has said that an MRI shows that the nerve roots from my lumbar spine are being "crushed." I have a fair amount of nerve damage to go with everything else.

Hello.. For one I know as a believer in Jesus Christ He alone can heal me.. I believe God does use medications. He alone sets the stage .. For me any biologic didnt work and honestly i take natural remedies.. I pray daily walk and watch my diet.. I know many that take medications and they have alot of other conditions, which I believe are side effects of the meds.. I know in my heart God will heal me with the natural and my cooperation in diet, exercise.. Im not dissing anyone who takes medications. I was in bed with pneumonia when i was on biologics. I have had pneumonia 4 times.. I am presently recovering from covid pneumonia from Jan 2020.. I have long haul and some days i just dont feel good.. So I pray you are healed and find the right cure. For me my faith is.. Jesus can only heal me.. Thanks for the reply.

What specifically do you take? I REFUSE to take biologics because of the potential toxic side effects.

Hello I take many different herbal supplements. I use tumeric and lots garlic. I do have a uV treatment machine that helps. My name is Frannie.

I take adalimumab for PsA . I chose that biologic after much
study of 20 years of research and use on patients with various diseases. It does halt most of the destruction of
tendons and joints in addition to lowering my heart disease risk.
Supplements that will help are CoQ10, turmeric if not overdosed, statin drugs, dark chocolate, vitamin D, and
melatonin. All above have study findings of being anti
inflammatory. Ask your rheumatologist about DHEA.
Suggest Mediterranean diet with gluten limitations and
use pure stevia instead of sugar. Coffee and colored vegetables with polyphenols are your friends. Stretching and sleep hygiene with the weight loss of a healthy diet all
contribute to balancing your immunity.

@mercyreigns it’s very important to not share an email address or phone number on MCC. This is a public site and we don’t want just anyone getting your address!

I have been on the biologic Rinvoq for seronegative rheumatoid arthritis and ended up in the ER from mucopurulent bronchitis. I was coughing so hard that I had a laryngospasm that left me unable to get air in or out for a frighting amount of time. After that I came down with all kinds of side effects from latent viruses and fungal infections that became reactivated. I was switched to Simponi Aria. I'm going through multiple side effects such as severe ones like gastritis, more pain and inflammation from DDD, joint pain, Modic Type 1 endplate degeneration and failed back surgery. I'm experiencing minor side effects like urinary urgency and incontinence, hair loss, severe headaches, weight loss, nausea, pain in eyes, severe stomach pain, diarrhea, anemia, sinusitis and bone and joint pain. I'm scheduled for another infusion in five days and I'm frightened that I will have gut ripping pain in my abdomen again where I will have to decide if I should take myself to the ER again which is a last resort.

Hello Frannie @mercyreigns, You will notice that we removed your email address to protect your privacy. Members can share personal contact information using the private message function of Connect. See the Help Center for more information - https://connect.mayoclinic.org/help-center/