I'm a little concerned re the hype and such that surrrounded Ohtuvayre as I have not heard many positive remarks and outstanding results that have occurred. The literature doe not address at what point one could experience in breathing easier, when one should expect improvement etc. Did the FDA truly scrutinize this medication before approval I think it was alot of hype.....especially after Dupixent was approved as well with those with copd, however only if they too had type II inflammation.