Sure, den01, I just looked at my gradient results back to 2021.

Remember, each case/patient is different, but for what it's worth:

I was asymptomatic until June 2024. Resting peak LVOT gradient was 173mmHg in April 2021 and 179mmHg in February 2023. I started on metoprolol in 2023, and tested 127mmHg in January 2024. (No results with Valsalva maneuver reported for these tests.)

Symptoms started (severe shortness of breath, sense of pressure in chest) in June 2024 at age 72. Tested 142mmHg in July 2024 (227mmHg with Valsalva). The SOB greatly improved after a few weeks, when a chest infection cleared up, but sense of pressure in chest persists to today.

I started on 5 mg mavacamten (Camzyos) in October 2024. Tested 61mmHg in November 2024 (123mmHg with Valsalva); 18mmHg in December 2024 (38mmHg with Valsalva); and 14mmHg in January 2025 (32mmHg with Valsalva).

So, the gradients are clearly going down, but I still feel pressure in chest, and SOB when doing even mild unaccustomed exercise (but no undue SOB when doing my usual aerobics or moderate weight-training in controlled circumstances at the gym).

I may be increasing to 10 mg mavacamten soon (meeting with doc later today). I am still strongly considering septal myectomy depending on how things go over the next few months.