MGUS can have all sorts of associated translocations and mutations. I also have gains on chromosomes 5, 7, and 9, but those supposedly buffer the 1q21 gain. Most of my non-MGUS bloodwork, including plasma level are OK. A bit low on red blood cells but that might be celiac associated. Life is best lived sooner than later. Before I got covid 2 years ago, I biked ~6000 mi/year. After long covid I still get in ~3000 mi/year plus cross training. BTW, peripheral nephropathy was why I was tested for MGUS (associated with that and celiac). It hasn't worsened over the years, but my hobbies keep my extremities working. I do take about 3 gm/day of bioavailable curcumin; works on lab rats to decrease TNF (tumor necrosis factor) so who knows. Regular turmeric and curcumin are poorly absorbed by the GI tract and low concentration. Adding peperine (from black pepper) and lipids (fats) increases absorption.