I have Chronic Eosinophilic Pneumonia and sinusitis (probably severe asthma but hard to tease that out of the rest of it right now). I cannot get under 10 mg of prednisone without relapsing so we tried Dupixent first since that targets it all. However, I felt awful after every injection and better and better the farther I got from the injection date. After the third injection, my pulmonoligst ordered a blood test and my blood eosinophils were 18% (lung capacity was also diminished), so we pivoted to Nucala.

After the first injections of Nucala (I do three injections, so 300 mg once a month), I had a lot of fatigue for about three days. I am fatigued regularly but this was seriously ramped up - but at least I could sleep versus being on 60 mg of prednisone (which is a living hell). I've had no other side effects and the fatigue faded after three days. I am three weeks out from those first injections and feel better than I have in months. It takes 6 months to see the effectiveness but I am already down to 15 mg of prednisone with no side effects or symptoms. I have lots of hope for this one!

Sending you the best while you decide if this is best for you and happy to answer any questions about my experiences.