I am a 66 year old male and newly introduced to the MGUS journey. Started with an echocardiogram showing an asymmetrical, moderately hypertrophic heart septal wall. My oral history report with providers at the University of Utah, HCM clinic triggered reasons to test for amyloid. Labs revealed monoclonal spike 0.99g/dl, IgG type lambda, but my free light chain ratio normal, 24 hour urine was negative.
Heart work up included PYP scan which was negative and MRI which also showed no clear signals of amyloid. My heart wall is a little thicker than normal 1.2cm but cardiologist thinks that is in a normal range for my size 6’5”/250lbs. Conclusion on heart; no reason at this time for heart biopsy.
My visit with amyloid/multiple myeloma specialist at the Huntsman Cancer Center in Salt Lake City, has me trending towards a MGUS diagnosis but next week is bone marrow biopsy, whole body bone scan and abdominal biopsy.