I take protonix (PPI) so I'm not sure if I can take pepsid or other meds like that as well. Haven't tried it. I did used to try tums before protonix and it did nothing for my burning. I mostly avoid meds due to side effects and would love to get off protonix as there are a lot of mixed reviews about PPIs. It's healing and has made my red esophagus pink again. I'll ask after my next scope. My brother died at 59 from esophageal cancer (had silent reflux so no symptoms) so I try to be cautious.