What can cause ANA titre of 1:2560?

I’m super late but currently my ana is 1:2560 I have sle, Sjögren’s syndrome. I was diagnosed in 2013 it took 2 years of being sick until death to confirm diagnosis

It doesn't sound like any type of hepatitis in my opinion.

I was in the same situation with you, having an ANA of 1:2560 and many of the same symptoms. It took 13 years for me finally to be diagnosed. In fact the criteria for scleroderma had to be changed (in about 2012) by an international consortium of scleroderma docs before my "Sine" variant of the disease could even be recognized. Even today many rheumatologists are unaware of the revision of the criteria for scleroderma.

Unfortunately in 2017, when you wrote, many rheumatologists were still not testing for the anticentromere B antibodies. And as for the ANA staining pattern, for years my "anticentromere staining pattern" was erroneously reported as a "speckled pattern."

When it finally was reported as an "anticentromere staining pattern" in 2003, I asked the rheumatologist for an anticentromere b blood test to confirm it, but the doc refused, saying, "You don't LOOK like you have scletoderma!" He then left to go work in another state.

It wasn't until my neurologist (yes, I was trying to find out why I had all of the pins and needles) witnessed me have an attack of Raynaud's in his chilly office, that I convinced HIM to order an anticentromere B test. It was highly positive.

I had the severe fatigue, the gastric reflux that can ultimately cause scarring in the esophagus with difficult swallowing. I had had recurrent cystitis for years. I had developed permanently puffy fingers, and huffing and puffing with exertion. I had shoulder problems and tendonitis here and there all over my body. And the rare attacks of Raynaud's. I had constipation, alternating with diarrhea, and bloating, and flatulence. Eventually even my kidney function became slightly impaired. The antibodies also attacked my thyroid, causing me hypothyroidism, weight gain, and obstructive sleep apnea and sleep problems. My eyes are very, very dry. A few years ago the antibodies even attacked my eyes irises, causing acute bilateral iritis that took months to resolve with prednisone eye drops.

At some point I decided to do a web search for "1:2560" and the only authoritative research articles listing ANA that high were about cases of scleroderma or lupus. In lupus the complement gets suppressed and is low, whereas in scleroderma the complement runs high. Mine was high.

Finally, I got to a Scleroderma Center at a major university hospital, and was diagnosed with what is now being called systemic sclerosis sine scleroderma. It's sleroderma, but without the hard skin. Four years later I went to a second Scleroderma Center, and the diagnosis was the same.

Along with this autoimmune disease I have elevated anticardiolipin antibodies which can cause blood clots, so I have been told to take an enteric coated baby aspirin daily.

My fatigue stems from the fact that it has affected both my heart and lungs. The echocardiogram, and a left heart catheterization revealed left ventricular diastolic dysfunction, basically a non-hypertrophic stiffening of the heart muscle. In the lungs, the pulmonary function tests revealed a reduction in lung diffusion (reduced DLCO) which is also typical for scleroderma.

The GI symptoms are also typical for scleroderma. It stiffens the gut slowing the passage of gut contents. So at first you have constipation, but eventually small bowel bacterial overgrowth which changes things to diarrhea with also the bloating and flatulence. So it tends to alternate between constipation and diarrhea.

The docs at these scleroderma centers both did nailfold capillaroscopy on me and confirmed I had some capillary changes "typical of scleroderma."

I think you should ask for an anticenromere B test if you are not absolutely certain whether you have had one.