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Is there anything to help stop or slow progression of MGUS?
Blood Cancers & Disorders | Last Active: 4 days ago | Replies (121)Comment receiving replies
@dcuste Good afternoon and Happy New Year. Hope you are doing well. I saved your post since we have IGM MGUS and have similar lab values. How did your PET scan turn out? I am going next week for low dose full body skeletal scan and on 1-23 I will have the bone marrow biopsy done. My hematologist agreed to wait on the full body organ CT scan with contrast until receiving the results of the tests this month. Were you concerned that your IGM jumped from 774 to 1608 in one year? Mine is going up about 100 points a year (now 697) and my IGG is similarly low like yours at 653 but has stayed in the 500+ to 600+ range for 3 years. My IGA is also very low at 48. (Range is 70-400) Hope to keep in touch with you as it seems most on the forum do not have IGM MGUS. Wishing you the best.
Replies to "@dcuste Good afternoon and Happy New Year. Hope you are doing well. I saved your post..."
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Happy New Year to you too. Hope you are doing well.
I had a PET scan a few years ago that was pretty clean. My Hematologist/Oncologist suggested another PET. We talked skeletal scan too, but I convinced to go with MRIs on Pelvis and lower spine with and without contrast. It's been 8 days since the scans and I only have the results of Pelvis with contrast so far.
Here is a Summary of MRI Findings....
Avascular Necrosis (AVN) of Both Femoral Heads:
Key Finding: There is evidence of AVN in both hips, which means compromised blood supply to the femoral heads leading to bone damage.
Good News: There is no collapse of the articular surface, indicating early-stage AVN.
Intertrochanteric Lesion in Left Femur:
Key Finding: An 8 mm rounded lesion is seen in the proximal left femur.
Interpretation: The lesion is T1/T2 hyperintense, possibly containing internal fat, which suggests it is likely benign. However, it is too small to characterize definitively.
Labrum of Left Hip:
Key Finding: Linear signal at the base of the anterosuperior labrum could indicate degenerative fraying or tearing, likely age-related.
Clinical Relevance: May contribute to hip pain or restricted movement.
Degenerative Changes in the Spine and Pelvis:
Pubic Symphysis and Sacroiliac Joints:
Mild degenerative changes noted, but no active sacroiliitis (inflammation).
Lower Lumbar Spine:
Advanced degenerative disc disease with levoscoliosis (leftward curvature of the spine).
Hamstring Tendons:
Key Finding: Mild tendinopathy of the hamstring origins.
Clinical Relevance: Likely not causing significant symptoms but could contribute to discomfort.
Left Inguinal Hernia:
Key Finding: Small fat-containing inguinal hernia on the left side.
Clinical Relevance: Unlikely to be symptomatic unless causing pain or other issues.
I wasn't expecting any of this. I have childhood friends that abused there bodies and are now paying the price. I've always been careful not to overdo it.
I'll wait for the other MRI results before I talk with my doctors, but right now I think the lesion may be MGUS related, but don't know. The biggest issue may be AVN. After a lot of research, my guess is both the AVN and possibly indirectly the MGUS, were caused by getting injected with steroids averaging 127mg/day for 43 days, 3 years ago. This was done to fight life threatening pneumonia.
Yes. Please stay in touch and let me know how your scan and BMB go. I'll let you know if anything new happens with me. I passed on the BMB earlier, but will reconsider once I get more test results. Good Luck. Hope your results are better than mine.