← Return to Looking for research re: taking AI drugs vs not taking them
DiscussionLooking for research re: taking AI drugs vs not taking them
Breast Cancer | Last Active: Jun 26 4:18pm | Replies (89)Comment receiving replies
Replies to "According to the NIH, taking an aromatase inhibitor reduces your risk for recurrence by about 53%...."
I think the 53% of reduction, to which this article refers, is prevention in women who are at risk for developing breast due to genetic factors or family history, for example, not for women who already have breast cancer. I have read that the risk reduction benefit from taking an aromatase inhibitor (AI) for 5 - 10 years after being diagnosed with ER+ breast cancer and after having had surgery and possibly radiation is 40% to 60%.
I was told that my chance of recurrence was 12% without taking an AI.
If I took an AI for at least 5 years, my risk would be between 7.2% and 4.8%. I had MANY side effects from anastrozole, the worst being severe depression and an overall poor quality of life. I was encouraged to try exemestane, but I declined. The hope of potentially reducing my risk of recurrence by less than 5%, was not worth feeling so awful for 5 -10 years, so I decided to stop taking anastrozole after 2 1/2 months. That was 4 years ago. I will be 75 in May. So far, I am doing well. I walk every day and eat a good diet.
I am not suggesting that anyone stop taking these drugs. It's a difficult, personal decision. Just know that it is your decision to make based on your situation and how you feel. I wish you all well. Try to be at peace with whatever decision you make. Sending hugs.
Agree!
Yes, this is the consensus of the studies I have read and also what was reported to me by my oncologist. Easily, there is a 30-50% reduction in recurrance of Estrogen Positive breast cancers (those that would be inhibited by the AI that inhibits Estrogen production, so the hormone not as available to trigger growth of any rogue cells with the Estrogen receptor and would therefore trigger growth). It is easy to find these studies with a google search (beware of the site as reputable)
I am on Exemestane (a steroid AI, one month) after trying the AI called anastrozole for 5 months. I had almost all of the negative side effects with anastrozole, so oncologist said let's try another. It is worth pressing on to find the right one, I figure going from an average 10% recurrance to 5% is worth it. Press on, we can do this.
That was from 2018. But that you for your answer