bone pain four months after Reclast Infusion

Hi, i am reaching out to anyone who has had or having major bone pain after receiving reclast. Three days after receiving my first infusion, I started having pain in my feet And ankles and it proceeded to move up through my calves, my legs and my hips and I’m trying to do some reading and how long that might last. I’m just trying to get some support. I appreciate any comments. Thank you.

I had 3 Reclast infusions over 4.5 years; the last was June 2023. The first infusion had flu-like symptoms for 5 days, brain fog, fatigue, joint aches, irregular heartbeat, and mild nausea. They tailed off quickly after that. The following two infusions had similar but far milder reactions. I have a few autoimmune diseases so am used to reacting to new drugs (even NSAIDs). The infusions did morph my osteoporosis into osteopenia (I'm 70 and do a lot of resistance/weights as well). If your symptoms continue, it would be good to connect with your doctor. https://www.ccjm.org/content/85/9/675 https://pmc.ncbi.nlm.nih.gov/articles/PMC10404464/

So its been approximately 4 moths since my Reclast infusion, and I continue to have issues from it. I had a very negative situation, and I realize everyone’s situation is different, people react differently, but, I have had what I call fallout from it. I was extremely sick for 5 days, and doctors think I may have had an allergic reaction. I am experiencing bone pain in feet, ankles, legs, knees, hips, joints. I notice issues relating to pain in teeth, jaws, and am so worried that maybe it could cause or is causing teeth issues now. I know I personally would not take the infusion again, But I realize that talking with many people, listening to the stories, will help me on the path to what I try next. All these stories and experiences has been so valuable and Im so thankful.

I had Reclast infusion Nov 12th, went thru flu like symptoms for 3 days, end of day 3 started with worst bone and joint pain ever. I was ready to go to the ER. Called clinic and was told to take Claritin along with ibuprofen and Tylenol. I took it for a month and started feeling better. So stopped to test if I still needed it. So far I've been good. Just normal arthritis pain I've always had. I told my NP that I won't be taking it again. I have a year, but next time it'll be something different for sure.

My reclast infusion was late January of 2024. About 10 hours after, I had the severe reaction (rib, back pain, dizziness, temp) some have experienced which lasted just a day or so then subsided. About 2-3 months later, I began having deep pain in my leg-hip to foot which varied in intensity for about 3 months before also subsiding in July. I feel like these are flare ups or waves of something going on as another flare up began late November and is just beginning to subside. The pain is worse at night and when standing from a sitting position. Walking helps and I am trying to balance rest with exercise. I have already told my Dr. I won't take the infusion again when due this month. She acknowledges that about 40% of people have musculoskeletal pain. I will follow to see how others manage this. Hope you feel better soon.

I am so glad that your doctor acknowledged that your pain was experienced by others, not just you. Some doctors are so close-mouthed about your condition, you would think it is a national secret. The best to you this year.

I'm very grateful to you and your doctor. I've been on the fence with bisphosphonates, but the more I read, the more I'm leaning towards natural help.
Doctors and clinical pharmacists always talk about side effects being rare. 40% does not sound rare.
Thank you for this post!

I have an endo appt this week. I am finishing up 18 months of tymlos. I know my doc will be discussing another medication. After reading up on Prolia and Reclast I am scared of these medications. Anyone here have experience with Fosomax?

I took it for over 5 years. I had none of the digestive side effects (acid reflux) or joint pain. However, I fractured at T8 at just over five years. I have since learned that it suppresses bone formation along with bone resorption.

Our bones are constantly developing microfractures as we use them. The bone remodeling process is critical for repairing those microfractures. When this process is stopped, our bones slowly become more brittle and compromised. This is why a drug “holiday” is recommended after being on Fosamax.

I had excellent gains in my T-score the first two years I was on it but then they started to deteriorate. I feel that stopping all bone remodeling is risky, especially for people who are constantly stressing their bones with exercise and activity. I believe this drug contributed to my fracture after five years.

I am trying to continue anabolic treatment (4 months of Tymlos) and working through issues with insurance coverage.

I realize that bisphosphonate treatment is recommended after anabolics and I would consider taking Fosamax again for a brief period - maybe one year.

At any rate I have enough Alendronate in my bones to last for years after taking it for five years so I would perhaps not take it.

I have MS and other health issues as well. I have a sensitivity to medicines but not long term and if I do I can change the medication right away, this one I stuck at the moment. Due to my health issues at 53 I had to start treatment and this was the next when she wanted me to go on. I’m 57 now I hope Mike more back to osteopenia I do do a lot of walking and Pilates, but I have not started resistant training. I know I’ve been told that will help. Thank you so much for responding. It means a lot to me to have support and others who share some of the same problems.